Literature DB >> 19362577

The potential of ghrelin as a prokinetic.

Pierre Poitras1, Catherine Tomasetto.   

Abstract

Ghrelin is a 28 amino-acid peptide discovered in 1999. It is synthesized mainly in endocrine cells of the gastric mucosa and secreted into the blood. Physiological contributions of the peptide in human include probably regulation of growth hormone and of appetite. Ghrelin can also influence the gastrointestinal system, mostly by stimulating the contractility of the proximal gut. Whether ghrelin is a significant regulator of the digestive physiology remains to be shown. Whether ghrelin agonist agents could be useful prokinetic drugs in human medicine is currently under exploration.

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Year:  2009        PMID： 19362577     DOI： 10.1016/j.regpep.2009.04.007

Source DB:  PubMed          Journal:  Regul Pept        ISSN： 0167-0115


  7 in total

1.  Ghrelin attenuates gastrointestinal epithelial damage induced by doxorubicin.

Authors:  Mohamed A Fahim; Hazem Kataya; Rkia El-Kharrag; Dena Am Amer; Basel al-Ramadi; Sherif M Karam
Journal:  World J Gastroenterol       Date:  2011-09-07       Impact factor: 5.742

2.  New ghrelin agonist, HM01 alleviates constipation and L-dopa-delayed gastric emptying in 6-hydroxydopamine rat model of Parkinson's disease.

Authors:  H Karasawa; C Pietra; C Giuliano; S Garcia-Rubio; X Xu; S Yakabi; Y Taché; L Wang
Journal:  Neurogastroenterol Motil       Date:  2014-10-19       Impact factor: 3.598

3.  The prokinetic face of ghrelin.

Authors:  Hanaa S Sallam; Jiande D Z Chen
Journal:  Int J Pept       Date:  2010-02-10

4.  The roles of motilin and ghrelin in gastrointestinal motility.

Authors:  Tetsuro Ohno; Erito Mochiki; Hiroyuki Kuwano
Journal:  Int J Pept       Date:  2010-02-03

5.  Correlations of circulating peptide YY and ghrelin with body weight, rate of weight gain, and time required to achieve the recommended daily intake in preterm infants.

Authors:  XiaFang Chen; XueLiang Du; JianXing Zhu; LiJuan Xie; YongJun Zhang; ZhenJuan He
Journal:  Braz J Med Biol Res       Date:  2012-04-26       Impact factor: 2.590

6.  Effect of DA-9701, a Novel Prokinetic Agent, on Post-operative Ileus in Rats.

Authors:  Sang Pyo Lee; Oh Young Lee; Kang Nyeong Lee; Hang Lak Lee; Ho Soon Choi; Byung Chul Yoon; Dae Won Jun
Journal:  J Neurogastroenterol Motil       Date:  2017-01-30       Impact factor: 4.924

7.  Multiple Beneficial Effects of Ghrelin Agonist, HM01 on Homeostasis Alterations in 6-Hydroxydopamine Model of Parkinson's Disease in Male Rats.

Authors:  Artem Minalyan; Lilit Gabrielyan; Claudio Pietra; Yvette Taché; Lixin Wang
Journal:  Front Integr Neurosci       Date:  2019-04-12
  7 in total

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