| Literature DB >> 19362473 |
Natalia Zotova1, Linda J Broadbelt, Alan Armstrong, Donna G Blackmond.
Abstract
Reaction progress kinetic analysis of the proline-mediated intermolecular aldol reaction shows that the rate depends on the concentrations of both the donor ketone1 and the electrophilic aldehyde 2, implying that enamine formation cannot be rate-determining. The observed kinetics and deuterium isotope effects are consistent with formation of the product iminium species as the rate-determining step.Entities:
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Year: 2009 PMID： 19362473 DOI： 10.1016/j.bmcl.2009.03.112
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823