| Literature DB >> 19362467 |
Charles Francavilla1, Eddy Low, Satheesh Nair, Bum Kim, Timothy P Shiau, Dmitri Debabov, Chris Celeri, Nichole Alvarez, Ashley Houchin, Ping Xu, Ron Najafi, Rakesh Jain.
Abstract
A series of backbone modified and sulfonic acid replacement analogs of our topical, clinical candidate (iii) were synthesized. Their antimicrobial activities and aqueous stabilities at pH 4 and pH 7 were determined, and has led us to identify quaternary ammonium N,N-dichloroamines as a new class of topical antimicrobial agents.Entities:
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Year: 2009 PMID： 19362467 DOI： 10.1016/j.bmcl.2009.03.120
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823