Literature DB >> 19361638

Transanal endorectal pull-through in children with Hirschsprung's disease--technical refinements and comparison of results with the Duhamel procedure.

Ana Cristina Aoun Tannuri1, Uenis Tannuri, Rodrigo Luiz Pinto Romão.   

Abstract

PURPOSE: Transanal endorectal pull-through (TEPT) has drastically changed the treatment of Hirschsprung's disease (HD). A short follow-up of children submitted to TEPT reveals results that are similar to the classic transabdominal pull-through procedures. However, few reports compare the late results of TEPT with transabdominal pull-through procedures with respect to complication rates and the fecal continence. The aims of the present work are to describe some technical refinements that we introduced in the procedure and to compare the short and long-term outcome of TEPT with the outcomes of a group of patients with HD who previously underwent the Duhamel procedure.
METHODS: Thirty-five patients who underwent TEPT were prospectively studied and compared to a group of 29 patients who were treated with colostomy followed by a classical Duhamel pull-through. The main modifications introduced in the TEPT group were no preoperative colon preparation, operation conducted under general anesthesia in addition to regional sacral anesthesia, use of only one purse-string suture in the rectal mucosa before transanal submucosal dissection, and no use of retractors and electrocautery during the submucosal dissection.
RESULTS: The most frequent early complications of TEPT group were perineal dermatitis (22.8%) and anastomotic strictures (8.6%). The comparison with patients who underwent Duhamel procedure revealed no difference in the incidence of preoperative enterocolitis, the patients of the TEPT group were younger at the time of diagnosis and of surgery, they had shorter operating times, and they began oral feeding more quickly after the operation. The incidence of wound infection was lower in the TEPT group. Moreover, the TEPT and Duhamel groups showed no difference in the incidences of mortality, postoperative partial continence, and total incontinence. Although the incidences of complete continence and postoperative enterocolitis were not different, a tendency to the increased incidence in the TEPT group was observed.
CONCLUSIONS: This study further supports the technical advantages, the simplicity, and the decreased incidence of complications of a primary TEPT procedure when compared to a classical form of pull-through. Some technical refinements are described, and no preoperative colon preparation was necessary for the patients studied here. The results show that the long-term outcomes of the modified TEPT procedure are generally better than those obtained with classical approaches.

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Year:  2009        PMID: 19361638     DOI: 10.1016/j.jpedsurg.2008.08.002

Source DB:  PubMed          Journal:  J Pediatr Surg        ISSN: 0022-3468            Impact factor:   2.545


  14 in total

Review 1.  Genetic interactions and modifier genes in Hirschsprung's disease.

Authors:  Adam S Wallace; Richard B Anderson
Journal:  World J Gastroenterol       Date:  2011-12-07       Impact factor: 5.742

2.  Evolution in the management of Hirschsprung's disease in the UK and Ireland: a national survey of practice revisited.

Authors:  T J Bradnock; G M Walker
Journal:  Ann R Coll Surg Engl       Date:  2010-08-24       Impact factor: 1.891

3.  Differentiation of GDNF and NT-3 dual gene-modified rat bone marrow mesenchymal stem cells into enteric neuron-like cells.

Authors:  Heyun Gao; Mingfa Wei; Yan Wang; Xiaojuan Wu; Tianqi Zhu
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2012-01-27

4.  One-stage transanal endorectal pull-through for treatment of hirschsprung's disease in adolescents and adults.

Authors:  Samir Ahmad Ammar; Ibrahim Ali Ibrahim
Journal:  J Gastrointest Surg       Date:  2011-09-10       Impact factor: 3.452

5.  Comparative review of functional outcomes post surgery for Hirschsprung's disease utilizing the paediatric incontinence and constipation scoring system.

Authors:  Olugbenga Michael Aworanti; Dermot Thomas Mcdowell; Ian Michael Martin; Judy Hung; Feargal Quinn
Journal:  Pediatr Surg Int       Date:  2012-09-22       Impact factor: 1.827

6.  A variant pattern of calretinin immunohistochemistry on rectal suction-biopsies is fully specific of short-segment Hirschsprung's disease.

Authors:  Vincent Guinard-Samuel; Arnaud Bonnard; Michel Peuchmaur; Dominique Berrebi
Journal:  Pediatr Surg Int       Date:  2014-06-20       Impact factor: 1.827

Review 7.  Long-term results of transanal pull-through for Hirschsprung's disease: a meta-analysis.

Authors:  J Zimmer; C Tomuschat; P Puri
Journal:  Pediatr Surg Int       Date:  2016-07-06       Impact factor: 1.827

8.  Single Stage Transanal Pull-Through for Hirschsprung's Disease in Neonates: Our Early Experience.

Authors:  Pradeep Bhatiav; S Rakesh Joshi; Jaishri Ramji; Mitesh Bachani; Amit Uttarwar
Journal:  J Neonatal Surg       Date:  2013-10-01

9.  One-stage laparoscopy-assisted endorectal pull-through for late presented Hirschsprung's disease-Case series.

Authors:  So Hyun Nam; Min Jeong Cho; Dae Yeon Kim
Journal:  Int J Surg Case Rep       Date:  2015-09-18

Review 10.  RET haplotype, not linked to the C620R activating mutation, associated with Hirschsprung disease in a novel MEN2 family.

Authors:  Elisangela P S Quedas; Viviane C Longuini; Tomoko Sekiya; Flavia L Coutinho; Sergio P A Toledo; Uenis Tannuri; Rodrigo A Toledo
Journal:  Clinics (Sao Paulo)       Date:  2012       Impact factor: 2.365

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