Literature DB >> 19360888

Analysis of the mechanical behavior of a titanium scaffold with a repeating unit-cell substructure.

Garrett Ryan1, Patrick McGarry, Abhay Pandit, Dimitrios Apatsidis.   

Abstract

Titanium scaffolds with controlled microarchitecture have been developed for load bearing orthopedic applications. The controlled microarchitecture refers to a repeating array of unit-cells, composed of sintered titanium powder, which make up the scaffold structure. The objective of this current research was to characterize the mechanical performance of three scaffolds with increasing porosity, using finite element analysis (FEA) and to compare the results with experimental data. Scaffolds were scanned using microcomputed tomography and FEA models were generated from the resulting computer models. Macroscale and unit-cell models of the scaffolds were created. The material properties of the sintered titanium powders were first evaluated in mechanical tests and the data used in the FEA. The macroscale and unit-cell FEA models proved to be a good predictor of Young's modulus and yield strength. Although macroscale models showed similar failure patterns and an expected trend in UCS, strain at UCS did not compare well with experimental data. Since a rapid prototyping method was used to create the scaffolds, the original CAD geometries of the scaffold were also evaluated using FEA but they did not reflect the mechanical properties of the physical scaffolds. This indicates that at present, determining the actual geometry of the scaffold through computed tomography imaging is important. Finally, a fatigue analysis was performed on the scaffold to simulate the loading conditions it would experience as a spinal interbody fusion device.

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Year:  2009        PMID: 19360888     DOI: 10.1002/jbm.b.31361

Source DB:  PubMed          Journal:  J Biomed Mater Res B Appl Biomater        ISSN: 1552-4973            Impact factor:   3.368


  4 in total

1.  The inter-sample structural variability of regular tissue-engineered scaffolds significantly affects the micromechanical local cell environment.

Authors:  A Campos Marin; D Lacroix
Journal:  Interface Focus       Date:  2015-04-06       Impact factor: 3.906

Review 2.  Additively Manufactured Scaffolds for Bone Tissue Engineering and the Prediction of their Mechanical Behavior: A Review.

Authors:  Xiang-Yu Zhang; Gang Fang; Jie Zhou
Journal:  Materials (Basel)       Date:  2017-01-10       Impact factor: 3.623

Review 3.  Stem cells in a three-dimensional scaffold environment.

Authors:  Xuan Meng; Patrick Leslie; Yanping Zhang; Jiahong Dong
Journal:  Springerplus       Date:  2014-02-11

Review 4.  The Use of Finite Element Analyses to Design and Fabricate Three-Dimensional Scaffolds for Skeletal Tissue Engineering.

Authors:  Wim J Hendrikson; Clemens A van Blitterswijk; Jeroen Rouwkema; Lorenzo Moroni
Journal:  Front Bioeng Biotechnol       Date:  2017-05-17
  4 in total

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