Literature DB >> 1936068

Induction of cytochrome P-450 isozymes upon repeated administration of nifedipine.

M Koleva1, T Stoytchev, L Gulyaeva, A Grishanova, V Mishin, V Lyakhovich.   

Abstract

In experiments on male Wistar rats it has been found that nifedipine administration at a dose of 10 mg/kg body weight i.p. daily for 20 days did not significantly increase the total amount of cytochrome P-450 but markedly increased the 7 alpha-, 16 beta- and 6 beta-hydroxylation of androstenedione in liver microsomes, suggesting the induction of cytochromes P-450IIA1, P-450IIB1, and P-450IIIA1, respectively. The induction of cytochrome P-450IIIB1 was also confirmed immunochemically with polyclonal antibodies against cytochrome P-450IIB1/B2.

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Year:  1991        PMID： 1936068     DOI： 10.1007/BF03189945

Source DB:  PubMed          Journal:  Eur J Drug Metab Pharmacokinet        ISSN： 0378-7966            Impact factor:   2.441


  20 in total

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Review 2.  The P450 superfamily: updated listing of all genes and recommended nomenclature for the chromosomal loci.

Authors:  D W Nebert; D R Nelson; M Adesnik; M J Coon; R W Estabrook; F J Gonzalez; F P Guengerich; I C Gunsalus; E F Johnson; B Kemper
Journal:  DNA       Date:  1989 Jan-Feb

3.  Immunochemical evidences that hexachlorobenzene induces two forms of cytochrome P-450 in the rat liver microsomes.

Authors:  N I Gutkina; V M Mishin
Journal:  Chem Biol Interact       Date:  1986-04       Impact factor: 5.192

4.  Regulation of cytochrome P-450. Immunochemical quantitation of eight isozymes in liver microsomes of rats treated with polybrominated biphenyl congeners.

Authors:  G A Dannan; F P Guengerich; L S Kaminsky; S D Aust
Journal:  J Biol Chem       Date:  1983-01-25       Impact factor: 5.157

5.  Activities of 3,4-benzpyrene hydroxylase systems reconstituted by means of self-assembly from control and 3-methylcholanthrene-induced liver microsomes of "susceptible" and "unsusceptible" mice.

Authors:  V V Lyakhovich; I B Tsyrlov; O A Gromova; N B Rivkind
Journal:  Biochem Biophys Res Commun       Date:  1978-04-28       Impact factor: 3.575

6.  Studies of the metabolism of diethyl p-nitrophenyl phosphorothionate (parathion) and benzphetamine using an apparently homogeneous preparation of rat liver cytochrome P-450: effect of a cytochrome P-450 antibody preparation.

Authors:  T Kamataki; D H Belcher; R A Neal
Journal:  Mol Pharmacol       Date:  1976-11       Impact factor: 4.436

7.  Rat hepatic cytochrome P-450 isoenzyme 2c. Identification as a male-specific, developmentally induced steroid 16 alpha-hydroxylase and comparison to a female-specific cytochrome P-450 isoenzyme.

Authors:  D J Waxman
Journal:  J Biol Chem       Date:  1984-12-25       Impact factor: 5.157

8.  Regulation of testosterone hydroxylation by rat liver microsomal cytochrome P-450.

Authors:  A J Sonderfan; M P Arlotto; D R Dutton; S K McMillen; A Parkinson
Journal:  Arch Biochem Biophys       Date:  1987-05-15       Impact factor: 4.013

9.  Regio- and stereoselective metabolism of two C19 steroids by five highly purified and reconstituted rat hepatic cytochrome P-450 isozymes.

Authors:  A W Wood; D E Ryan; P E Thomas; W Levin
Journal:  J Biol Chem       Date:  1983-07-25       Impact factor: 5.157

10.  A high-spin form of cytochrome P-450 highly purified from polychlorinated biphenyl-treated rats. Catalytic characterization and immunochemical quantitation in liver microsomes.

Authors:  T Kamataki; K Maeda; Y Yamazoe; N Matsuda; K Ishii; R Kato
Journal:  Mol Pharmacol       Date:  1983-07       Impact factor: 4.436
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  1 in total

1.  On the enzyme-inducing action of calcium antagonists.

Authors:  M Koleva; T Stoytchev
Journal:  Arch Toxicol       Date:  1993       Impact factor: 5.153
  1 in total

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