Literature DB >> 19360171

Organocatalytic asymmetric synthesis of chiral fluorinated quaternary carbon containing beta-ketoesters.

Hao Li1, Shilei Zhang, Chenguang Yu, Xixi Song, Wei Wang.   

Abstract

Organocatalytic enantioselective conjugate addition of alpha-fluoroketoesters to nitroolefins efficiently catalyzed by a cinchona alkaloid-derivative affords versatile non-enolizable ketoesters by forming two consecutive fluorinated quaternary and tertiary chiral carbon centers with excellent enantioselectivity.

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Year:  2009        PMID： 19360171     DOI： 10.1039/b900777f

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  4 in total

Review 1.  Modern Approaches for Asymmetric Construction of Carbon-Fluorine Quaternary Stereogenic Centers: Synthetic Challenges and Pharmaceutical Needs.

Authors:  Yi Zhu; Jianlin Han; Jiandong Wang; Norio Shibata; Mikiko Sodeoka; Vadim A Soloshonok; Jaime A S Coelho; F Dean Toste
Journal:  Chem Rev       Date:  2018-04-02       Impact factor: 60.622

2.  Synthesis of 3,4-Dihydro-2H-Pyrroles from Ketones, Aldehydes, and Nitro Alkanes via Hydrogenative Cyclization.

Authors:  Barbara Klausfelder; Patricia Blach; Niels de Jonge; Rhett Kempe
Journal:  Chemistry       Date:  2022-07-06       Impact factor: 5.020

3.  One-pot Fluorination and Organocatalytic Robinson Annulation for Asymmetric Synthesis of Mono- and Difluorinated Cyclohexenones.

Authors:  Xin Huang; Weizhao Zhao; Xiaofeng Zhang; Miao Liu; Stanley N S Vasconcelos; Wei Zhang
Journal:  Molecules       Date:  2018-09-04       Impact factor: 4.411

Review 4.  Chiral Thioureas-Preparation and Significance in Asymmetric Synthesis and Medicinal Chemistry.

Authors:  Franz Steppeler; Dominika Iwan; Elżbieta Wojaczyńska; Jacek Wojaczyński
Journal:  Molecules       Date:  2020-01-18       Impact factor: 4.411
  4 in total

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