OBJECTIVES: The aim of this study was to assess the value of power Doppler ultrasound (PDUS) in combination with routine management in a cohort of patients with very early inflammatory arthritis (IA). METHODS: 50 patients with < or =12 weeks of inflammatory symptoms with or without signs had clinical, laboratory and imaging assessments. Diagnosis was recorded at 12 months. Assuming a 15% pre-test probability of IA, post-test probabilities for various assessments were calculated and used to develop a diagnostic algorithm. RESULTS: All patients positive for rheumatoid factor (RF) and/or cyclic citrullinated peptide (CCP) developed persistent IA, so the added value of PDUS was assessed in the seronegative (RF and CCP negative) group. The probability of IA in a seronegative patient was 6%. The addition of clinical and radiographic features raised the probability of IA to 30% and, with certain ultrasound features, this rose to 94%. CONCLUSIONS: In seronegative patients with early IA, combining PDUS with routine assessment can have a major impact on the certainty of diagnosis.
OBJECTIVES: The aim of this study was to assess the value of power Doppler ultrasound (PDUS) in combination with routine management in a cohort of patients with very early inflammatory arthritis (IA). METHODS: 50 patients with < or =12 weeks of inflammatory symptoms with or without signs had clinical, laboratory and imaging assessments. Diagnosis was recorded at 12 months. Assuming a 15% pre-test probability of IA, post-test probabilities for various assessments were calculated and used to develop a diagnostic algorithm. RESULTS: All patients positive for rheumatoid factor (RF) and/or cyclic citrullinated peptide (CCP) developed persistent IA, so the added value of PDUS was assessed in the seronegative (RF and CCP negative) group. The probability of IA in a seronegative patient was 6%. The addition of clinical and radiographic features raised the probability of IA to 30% and, with certain ultrasound features, this rose to 94%. CONCLUSIONS: In seronegative patients with early IA, combining PDUS with routine assessment can have a major impact on the certainty of diagnosis.
Authors: Emilio Filippucci; Edoardo Cipolletta; Riccardo Mashadi Mirza; Marina Carotti; Andrea Giovagnoni; Fausto Salaffi; Marika Tardella; Andrea Di Matteo; Marco Di Carlo Journal: Radiol Med Date: 2019-03-09 Impact factor: 3.469
Authors: David F Ten Cate; Jolanda J Luime; Nanno Swen; Andreas H Gerards; Mike H De Jager; Natalja M Basoski; Johanna M W Hazes; Cees J Haagsma; Johannes W G Jacobs Journal: Arthritis Res Ther Date: 2013-01-08 Impact factor: 5.156
Authors: Lotte A van de Stadt; Wouter H Bos; Marlies Meursinge Reynders; Helen Wieringa; Franktien Turkstra; Conny J van der Laken; Dirkjan van Schaardenburg Journal: Arthritis Res Ther Date: 2010-05-20 Impact factor: 5.156