| Literature DB >> 19359173 |
Giuseppe Giannini1, Mauro Marzi, Maria Di Marzo, Gianfranco Battistuzzi, Riccardo Pezzi, Tiziana Brunetti, Walter Cabri, Loredana Vesci, Claudio Pisano.
Abstract
In order to gather further knowledge about the structural requirements on histone deacetylase inhibitors (HDACi), starting from the schematic model of the common pharmacophore that characterizes this class of molecules (surface recognition CAP group-connection unit-linker region-Zinc Binding Group), we designed and synthesized a series of hydroxamic acids containing a bis-(indolyl)methane moiety. HDAC inhibition profile and antiproliferative activity were evaluated.Entities:
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Year: 2009 PMID： 19359173 DOI： 10.1016/j.bmcl.2009.03.101
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823