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Literature DB >> 19359168

Synthesis and characterization of a BODIPY-labeled derivative of Soraphen A that binds to acetyl-CoA carboxylase.

Brian Raymer¹, Michael Kavana, Allen Price, Bing Wang, Lisa Corcoran, Raviraj Kulathila, James Groarke, Theirry Mann.

Abstract

BODIPY-labeled Soraphen A derivative 4 was synthesized and characterized as an acetyl-CoA carboxylase (ACC) binder. Biophysical measurements indicate that the molecule binds in the biotin carboxylase domain where Soraphen A has been shown to bind. The fluorescent label of the BODIPY can be used to biophysically identify a compound that binds to the Soraphen A site of the biotin carboxylase domain versus the carboxytransferase domain of ACC.

Entities: Chemical

Mesh：

Substances：

Year: 2009 PMID： 19359168 DOI： 10.1016/j.bmcl.2009.03.107

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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Cited

7 in total

1. Synthesis of C11-Desmethoxy Soraphen A_1α: A natural product analog that inhibits acetyl-CoA carboxylase.

Authors: Daniel P Canterbury; Kristen E N Scott; Ozora Kubo; Rolf Jansen; John L Cleveland; Glenn C Micalizio
Journal: ACS Med Chem Lett Date: 2013-12-12 Impact factor: 4.345

2. Elevated hepatic fatty acid elongase-5 activity corrects dietary fat-induced hyperglycemia in obese C57BL/6J mice.

Authors: Sasmita Tripathy; Moises Torres-Gonzalez; Donald B Jump
Journal: J Lipid Res Date: 2010-05-19 Impact factor: 5.922

3. Robust Chemical Strategy for Stably Labeling Polyester-Based Nanoparticles with BODIPY Fluorophores.

Authors: Ivan S Alferiev; Ilia Fishbein; Robert J Levy; Michael Chorny
Journal: ACS Appl Polym Mater Date: 2022-01-06

4. Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats.

Authors: Geraldine Harriman; Jeremy Greenwood; Sathesh Bhat; Xinyi Huang; Ruiying Wang; Debamita Paul; Liang Tong; Asish K Saha; William F Westlin; Rosana Kapeller; H James Harwood
Journal: Proc Natl Acad Sci U S A Date: 2016-03-14 Impact factor: 11.205

Synthesis and characterization of a BODIPY-labeled derivative of Soraphen A that binds to acetyl-CoA carboxylase.

1. Synthesis of C11-Desmethoxy Soraphen A_1α: A natural product analog that inhibits acetyl-CoA carboxylase.

2. Elevated hepatic fatty acid elongase-5 activity corrects dietary fat-induced hyperglycemia in obese C57BL/6J mice.

3. Robust Chemical Strategy for Stably Labeling Polyester-Based Nanoparticles with BODIPY Fluorophores.

4. Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats.

Review 5. Structure and function of biotin-dependent carboxylases.

6. Chemical inhibition of acetyl-CoA carboxylase suppresses self-renewal growth of cancer stem cells.

7. Crystal structure of the 500-kDa yeast acetyl-CoA carboxylase holoenzyme dimer.

Synthesis and characterization of a BODIPY-labeled derivative of Soraphen A that binds to acetyl-CoA carboxylase.

1. Synthesis of C11-Desmethoxy Soraphen A1α: A natural product analog that inhibits acetyl-CoA carboxylase.

2. Elevated hepatic fatty acid elongase-5 activity corrects dietary fat-induced hyperglycemia in obese C57BL/6J mice.

3. Robust Chemical Strategy for Stably Labeling Polyester-Based Nanoparticles with BODIPY Fluorophores.

4. Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats.

Review 5. Structure and function of biotin-dependent carboxylases.

6. Chemical inhibition of acetyl-CoA carboxylase suppresses self-renewal growth of cancer stem cells.

7. Crystal structure of the 500-kDa yeast acetyl-CoA carboxylase holoenzyme dimer.

1. Synthesis of C11-Desmethoxy Soraphen A_1α: A natural product analog that inhibits acetyl-CoA carboxylase.