Highly enantioselective Cu-catalyzed conjugate addition-elimination of activated allylic acetates with glycine derivatives.

The reaction of a glycinate Schiff base with the activated alkyl- and aryl-substituted allylic acetates afforded 4-alkylidenylglutamic acid derivatives in high yields and high enantioselectivities by using Cu/P,N-FcPhox as the catalyst.