Literature DB >> 19358565

Brartemicin, an inhibitor of tumor cell invasion from the actinomycete Nonomuraea sp.

Yasuhiro Igarashi1, Tsukasa Mogi, Saeko Yanase, Satoshi Miyanaga, Tsuyoshi Fujita, Hiroaki Sakurai, Ikuo Saiki, Ayumi Ohsaki.   

Abstract

Brartemicin (1), a new trehalose-derived metabolite, was isolated from the culture broth of the actinomycete of the genus Nonomuraea. Its structure and absolute configuration were determined by spectroscopic analyses. The new compound inhibited the invasion of murine colon carcinoma 26-L5 cells with an IC(50) value of 0.39 microM in a concentration-dependent manner without showing cytotoxic effects.

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Year:  2009        PMID： 19358565     DOI： 10.1021/np9000575

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  13 in total

1.  Tailoring Trehalose for Biomedical and Biotechnological Applications.

Authors:  Mara K O'Neill; Brent F Piligian; Claire D Olson; Peter J Woodruff; Benjamin M Swarts
Journal:  Pure Appl Chem       Date:  2017-01-11       Impact factor: 2.453

2.  Aryl Trehalose Derivatives as Vaccine Adjuvants for Mycobacterium tuberculosis.

Authors:  Kendal T Ryter; George Ettenger; Omer K Rasheed; Cassandra Buhl; Robert Child; Shannon M Miller; David Holley; Alyson J Smith; Jay T Evans
Journal:  J Med Chem       Date:  2019-12-20       Impact factor: 7.446

3.  Anti-neovascularization effects of DMBT in age-related macular degeneration by inhibition of VEGF secretion through ROS-dependent signaling pathway.

Authors:  Shang Chen; Yue Zhou; Lichun Zhou; Yanhui Guan; Yu Zhang; Xiuzhen Han
Journal:  Mol Cell Biochem       Date:  2018-02-14       Impact factor: 3.396

Review 4.  The secondary metabolites of rare actinomycetes: chemistry and bioactivity.

Authors:  Ting Ding; Luo-Jie Yang; Wei-Dong Zhang; Yun-Heng Shen
Journal:  RSC Adv       Date:  2019-07-16       Impact factor: 4.036

Review 5.  Endophytic actinobacteria of medicinal plants: diversity and bioactivity.

Authors:  Patrycja Golinska; Magdalena Wypij; Gauravi Agarkar; Dnyaneshwar Rathod; Hanna Dahm; Mahendra Rai
Journal:  Antonie Van Leeuwenhoek       Date:  2015-06-21       Impact factor: 2.271

6.  Biodiversity, Anti-Trypanosomal Activity Screening, and Metabolomic Profiling of Actinomycetes Isolated from Mediterranean Sponges.

Authors:  Cheng Cheng; Lynsey MacIntyre; Usama Ramadan Abdelmohsen; Hannes Horn; Paraskevi N Polymenakou; RuAngelie Edrada-Ebel; Ute Hentschel
Journal:  PLoS One       Date:  2015-09-25       Impact factor: 3.240

7.  The natural product brartemicin is a high affinity ligand for the carbohydrate-recognition domain of the macrophage receptor mincle.

Authors:  Kristian M Jacobsen; Ulrik B Keiding; Lise L Clement; Eva S Schaffert; Neela D S Rambaruth; Mogens Johannsen; Kurt Drickamer; Thomas B Poulsen
Journal:  Medchemcomm       Date:  2015-01-07       Impact factor: 3.597

Review 8.  Sensing Lipids with Mincle: Structure and Function.

Authors:  Spencer J Williams
Journal:  Front Immunol       Date:  2017-11-27       Impact factor: 7.561

Review 9.  Macrophage Inducible C-Type Lectin As a Multifunctional Player in Immunity.

Authors:  Emmanuel C Patin; Selinda Jane Orr; Ulrich E Schaible
Journal:  Front Immunol       Date:  2017-07-25       Impact factor: 7.561

Review 10.  Identification and Biological Activity of Synthetic Macrophage Inducible C-Type Lectin Ligands.

Authors:  Chriselle D Braganza; Thomas Teunissen; Mattie S M Timmer; Bridget L Stocker
Journal:  Front Immunol       Date:  2018-01-17       Impact factor: 7.561
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