| Literature DB >> 19356930 |
T Santhosh Kumar1, Michael E Ostergaard, Pawan K Sharma, Poul Nielsen, Jesper Wengel, Patrick J Hrdlicka.
Abstract
A short synthetic route to the first beta-l-ribo configured locked nucleic acid (LNA), that is, 2'-amino-beta-l-LNA thymine phosphoramidite 6, has been developed from bicyclic nucleoside 1. Incorporation of 2'-amino-beta-l-LNA thymine monomers into alpha-DNA strands results in probes forming stable duplexes with complementary RNA in parallel orientation.Entities:
Mesh：
Substances：
Year: 2009 PMID： 19356930 DOI： 10.1016/j.bmcl.2009.03.079
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823