OBJECTIVE: To compare endometrial tissue samples from cesarean scar (CS) sites and from the posterior uterine wall to better understand the pathophysiology of implantation into a CS. METHODS: Endometrial samples were taken from both a CS site and the posterior wall in premenopausal women with CSs, and from the posterior wall in premenopausal women who had spontaneous vaginal deliveries (SVDs) only. RESULTS: In the secretory phase, there were significantly fewer leukocytes at CS sites than in the endometrium of women who had SVDs only (P<0.05). Significant differences in leukocytic infiltration and cell proliferation between the proliferative and secretory phases were only found in women who had SVDs only (P<0.05). CONCLUSION: Leukocyte recruitment to the endometrium during the secretory phase may be affected by the presence of a CS.
OBJECTIVE: To compare endometrial tissue samples from cesarean scar (CS) sites and from the posterior uterine wall to better understand the pathophysiology of implantation into a CS. METHODS: Endometrial samples were taken from both a CS site and the posterior wall in premenopausal women with CSs, and from the posterior wall in premenopausal women who had spontaneous vaginal deliveries (SVDs) only. RESULTS: In the secretory phase, there were significantly fewer leukocytes at CS sites than in the endometrium of women who had SVDs only (P<0.05). Significant differences in leukocytic infiltration and cell proliferation between the proliferative and secretory phases were only found in women who had SVDs only (P<0.05). CONCLUSION: Leukocyte recruitment to the endometrium during the secretory phase may be affected by the presence of a CS.
Authors: Run Xin Gan; Yuan Li; Juan Song; Quan Wen; Guang Xiu Lu; Ge Lin; Fei Gong Journal: Front Endocrinol (Lausanne) Date: 2022-06-30 Impact factor: 6.055
Authors: Roman Eremichev; Maria Kulebyakina; Nataliya Alexandrushkina; Peter Nimiritsky; Nataliya Basalova; Olga Grigorieva; Mane Egiazaryan; Daniyar Dyikanov; Vsevolod Tkachuk; Pavel Makarevich Journal: Front Cell Dev Biol Date: 2021-02-25