Literature DB >> 19356709

The insulin receptor talks to glucagon?

Jesper Gromada1, Alokesh Duttaroy, Patrik Rorsman.   

Abstract

Type 2 diabetes (T2DM) is not only a disorder of impaired insulin secretion but also glucagon oversecretion. However, the link between the two remains unclear. Is it possible that the latter is a consequence of the former? In this issue, Kawamori et al. (2009) have addressed this question by generating alpha cell-specific insulin receptor knockout mice.

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Year:  2009        PMID: 19356709     DOI: 10.1016/j.cmet.2009.03.008

Source DB:  PubMed          Journal:  Cell Metab        ISSN: 1550-4131            Impact factor:   27.287


  8 in total

1.  Delayed onset of hyperglycaemia in a mouse model with impaired glucagon secretion demonstrates that dysregulated glucagon secretion promotes hyperglycaemia and type 2 diabetes.

Authors:  N Gustavsson; T Seah; Y Lao; G K Radda; T C Südhof; W Han
Journal:  Diabetologia       Date:  2010-10-27       Impact factor: 10.122

2.  Comparison of the physiological relevance of systemic vs. portal insulin delivery to evaluate whole body glucose flux during an insulin clamp.

Authors:  Tiffany D Farmer; Erin C Jenkins; Tracy P O'Brien; Gregory A McCoy; Allison E Havlik; Erik R Nass; Wendell E Nicholson; Richard L Printz; Masakazu Shiota
Journal:  Am J Physiol Endocrinol Metab       Date:  2014-12-16       Impact factor: 4.310

3.  Inhibition or deletion of soluble epoxide hydrolase prevents hyperglycemia, promotes insulin secretion, and reduces islet apoptosis.

Authors:  Pengcheng Luo; Hsin-Hsin Chang; Yiqiang Zhou; Shali Zhang; Sung Hee Hwang; Christophe Morisseau; Cong-Yi Wang; Edward W Inscho; Bruce D Hammock; Mong-Heng Wang
Journal:  J Pharmacol Exp Ther       Date:  2010-05-03       Impact factor: 4.030

4.  Novel Mechanism of Foxo1 Phosphorylation in Glucagon Signaling in Control of Glucose Homeostasis.

Authors:  Yuxin Wu; Quan Pan; Hui Yan; Kebin Zhang; Xiaoqin Guo; Zihui Xu; Wanbao Yang; Yajuan Qi; Cathy A Guo; Caitlyn Hornsby; Lin Zhang; Aimin Zhou; Ling Li; Yunmei Chen; Weiping Zhang; Yuxiang Sun; Hongting Zheng; Fred Wondisford; Ling He; Shaodong Guo
Journal:  Diabetes       Date:  2018-09-10       Impact factor: 9.461

5.  Heme Oxygenase-1 Regulates Ferrous Iron and Foxo1 in Control of Hepatic Gluconeogenesis.

Authors:  Wang Liao; Wanbao Yang; Zheng Shen; Weiqi Ai; Quan Pan; Yuxiang Sun; Shaodong Guo
Journal:  Diabetes       Date:  2021-01-06       Impact factor: 9.461

Review 6.  ATP-regulated potassium channels and voltage-gated calcium channels in pancreatic alpha and beta cells: similar functions but reciprocal effects on secretion.

Authors:  Patrik Rorsman; Reshma Ramracheya; Nils J G Rorsman; Quan Zhang
Journal:  Diabetologia       Date:  2014-06-07       Impact factor: 10.122

7.  Isosteviol has beneficial effects on palmitate-induced α-cell dysfunction and gene expression.

Authors:  Xiaoping Chen; Kjeld Hermansen; Jianzhong Xiao; Sara Kjaergaard Bystrup; Lorraine O'Driscoll; Per Bendix Jeppesen
Journal:  PLoS One       Date:  2012-03-27       Impact factor: 3.240

8.  Pea Protein-Derived Peptides Inhibit Hepatic Glucose Production via the Gluconeogenic Signaling in the AML-12 Cells.

Authors:  Wang Liao; Xinyi Cao; Hui Xia; Shaokang Wang; Guiju Sun
Journal:  Int J Environ Res Public Health       Date:  2022-08-18       Impact factor: 4.614

  8 in total

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