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Literature DB >> 19356073

Investigations into the drug-drug interaction potential of tapentadol in human liver microsomes and fresh human hepatocytes.

Christa Kneip¹, Rolf Terlinden, Horst Beier, Genfu Chen.

Abstract

The new analgesic tapentadol was evaluated for induction and inhibition of several cytochrome P450 enzymes in vitro, and protein binding was assessed. It was concluded that no clinically relevant drug-drug interactions are likely to occur through either mechanism.

Entities: Chemical Species

Mesh：

Substances：

Year: 2008 PMID： 19356073 DOI： 10.2174/187231208783478434

Source DB: PubMed Journal: Drug Metab Lett ISSN： 1872-3128

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Cited

15 in total

Review 1. Implications of opioid analgesia for medically complicated patients.

Authors: Howard Smith; Patricia Bruckenthal
Journal: Drugs Aging Date: 2010-05 Impact factor: 3.923

Review 2. Tapentadol immediate release: a review of its use in the treatment of moderate to severe acute pain.

Authors: James E Frampton
Journal: Drugs Date: 2010-09-10 Impact factor: 9.546

Review 3. [Tapentadol: with two mechanisms of action in one molecule effective against nociceptive and neuropathic pain. Preclinical overview].

Authors: T M Tzschentke; T Christoph; W Schröder; W Englberger; J De Vry; U Jahnel; B Y Kögel
Journal: Schmerz Date: 2011-02 Impact factor: 1.107

Review 4. Tapentadol in pain management: a μ-opioid receptor agonist and noradrenaline reuptake inhibitor.

Authors: Craig T Hartrick; Richard J Rozek
Journal: CNS Drugs Date: 2011-05 Impact factor: 5.749

5. Multiple Dose Pharmacokinetics of Tapentadol Oral Solution for the Treatment of Moderate to Severe Acute Pain in Children Aged 2 to <7 Years.

Authors: Renata Jończyk; Christoph Beuter; Beata Bulawa; Stefan Buller; Christoph Eibl; Christian Elling; Michael Gautrois; Jens Rengelshausen; Carsten Schmidt; Guido Thömmes; Feras Khalil
Journal: J Pain Res Date: 2022-09-30 Impact factor: 2.832

Investigations into the drug-drug interaction potential of tapentadol in human liver microsomes and fresh human hepatocytes.

Review 1. Implications of opioid analgesia for medically complicated patients.

Review 2. Tapentadol immediate release: a review of its use in the treatment of moderate to severe acute pain.

Review 3. [Tapentadol: with two mechanisms of action in one molecule effective against nociceptive and neuropathic pain. Preclinical overview].

Review 4. Tapentadol in pain management: a μ-opioid receptor agonist and noradrenaline reuptake inhibitor.

5. Multiple Dose Pharmacokinetics of Tapentadol Oral Solution for the Treatment of Moderate to Severe Acute Pain in Children Aged 2 to <7 Years.

6. Effects of CYP2C19 variants on the metabolism of tapentadol in vitro.

7. Population pharmacokinetic modeling to facilitate dose selection of tapentadol in the pediatric population.

Review 8. Tapentadol hydrochloride: A novel analgesic.

9. Tapentadol immediate release: a new treatment option for acute pain management.

10. Tapentadol extended-release for treatment of chronic pain: a review.