Literature DB >> 19356059

In vitro metabolism of leflunomide by mouse and human liver microsomes.

Eric C Y Chan1, Lee-Sun New.   

Abstract

Leflunomide was found to be metabolized predominantly to A77-1726 and two novel hydroxylated metabolites, M1 and M2, in microsomes while A77-1726 was only biotransformed to M1. M1 and M2 were proposed to be the hydroxylated alpha-cyanoenol form of A77-1726 and the hydroxylated 5 methyl-isoxazole form of leflunomide, respectively.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 19356059     DOI： 10.2174/187231207783221402

Source DB:  PubMed          Journal:  Drug Metab Lett        ISSN： 1872-3128


  2 in total

1.  Polymorphisms in cytochrome P450 2C19 enzyme and cessation of leflunomide in patients with rheumatoid arthritis.

Authors:  Michael D Wiese; Matthew Schnabl; Catherine O'Doherty; Llewellyn D Spargo; Michael J Sorich; Leslie G Cleland; Susanna M Proudman
Journal:  Arthritis Res Ther       Date:  2012-07-12       Impact factor: 5.156

2.  Role of oral teriflunomide in the management of multiple sclerosis.

Authors:  Radu Tanasescu; Nikos Evangelou; Cris S Constantinescu
Journal:  Neuropsychiatr Dis Treat       Date:  2013-04-22       Impact factor: 2.570
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.