Literature DB >> 19356014

ABCB1, SLCO1B1 and UGT1A1 gene polymorphisms are associated with toxicity in metastatic colorectal cancer patients treated with first-line irinotecan.

Katrin E Rhodes1, Wu Zhang, Dongyun Yang, Oliver A Press, Michael Gordon, Daniel Vallböhmer, Anne M Schultheis, Georg Lurje, Robert D Ladner, William Fazzone, Syma Iqbal, Heinz-Josef Lenz.   

Abstract

We tested specific gene polymorphisms known to be involved in the irinotecan (CPT-11) metabolic pathway. The combination of at least one SLCO1B1 521 T allele, one ABCB1 1236 C allele and one UGT1A1*28 variant 7 repeat demonstrated a statistically significant association with Grade 3/4 toxicities in metastatic colorectal cancer patients.

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Year:  2007        PMID： 19356014     DOI： 10.2174/187231207779814328

Source DB:  PubMed          Journal:  Drug Metab Lett        ISSN： 1872-3128


  14 in total

1.  Clinical implications of UGT1A1*28 genotype testing in colorectal cancer patients.

Authors:  Katerina Shulman; Ilana Cohen; Ofra Barnett-Griness; Abraham Kuten; Stephen B Gruber; Flavio Lejbkowicz; Gad Rennert
Journal:  Cancer       Date:  2011-02-01       Impact factor: 6.860

Review 2.  Personalized medicine: is it a pharmacogenetic mirage?

Authors:  Rashmi R Shah; Devron R Shah
Journal:  Br J Clin Pharmacol       Date:  2012-10       Impact factor: 4.335

3.  Analytical Validation of Variants to Aid in Genotype-Guided Therapy for Oncology.

Authors:  Marelize Swart; Wesley M Stansberry; Victoria M Pratt; Elizabeth B Medeiros; Patrick J Kiel; Fei Shen; Bryan P Schneider; Todd C Skaar
Journal:  J Mol Diagn       Date:  2019-02-20       Impact factor: 5.568

Review 4.  Pharmacogenetics research on chemotherapy resistance in colorectal cancer over the last 20 years.

Authors:  Mariusz Panczyk
Journal:  World J Gastroenterol       Date:  2014-08-07       Impact factor: 5.742

5.  Genetic Variant of CXCR1 (rs2234671) Associates with Clinical Outcome in Perihilar Cholangiocarcinoma.

Authors:  Isabella Lurje; Zoltan Czigany; Jan Bednarsch; Nadine Therese Gaisa; Edgar Dahl; Ruth Knüchel; Hannah Miller; Tom Florian Ulmer; Pavel Strnad; Christian Trautwein; Frank Tacke; Ulf Peter Neumann; Georg Lurje
Journal:  Liver Cancer       Date:  2022-01-25       Impact factor: 12.430

Review 6.  The Road so Far in Colorectal Cancer Pharmacogenomics: Are We Closer to Individualised Treatment?

Authors:  Ana Rita Simões; Ceres Fernández-Rozadilla; Olalla Maroñas; Ángel Carracedo
Journal:  J Pers Med       Date:  2020-11-19

7.  ABCB1 4036A>G and 1236C>T Polymorphisms Affect Plasma Efavirenz Levels in South African HIV/AIDS Patients.

Authors:  Marelize Swart; Yuan Ren; Peter Smith; Collet Dandara
Journal:  Front Genet       Date:  2012-11-05       Impact factor: 4.599

8.  Association between UGT1A1*28 polymorphisms and clinical outcomes of irinotecan-based chemotherapies in colorectal cancer: a meta-analysis in Caucasians.

Authors:  Xiang Liu; Dangxiao Cheng; Qin Kuang; Geoffrey Liu; Wei Xu
Journal:  PLoS One       Date:  2013-03-14       Impact factor: 3.240

9.  Association of UGT1A1*28 polymorphisms with irinotecan-induced toxicities in colorectal cancer: a meta-analysis in Caucasians.

Authors:  X Liu; D Cheng; Q Kuang; G Liu; W Xu
Journal:  Pharmacogenomics J       Date:  2013-03-26       Impact factor: 3.550

Review 10.  Solute carrier transporters: potential targets for digestive system neoplasms.

Authors:  Jing Xie; Xiao Yan Zhu; Lu Ming Liu; Zhi Qiang Meng
Journal:  Cancer Manag Res       Date:  2018-01-24       Impact factor: 3.989
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