Literature DB >> 19356010

Effect of common NAT2 variant alleles in the acetylation of the major clonazepam metabolite, 7-aminoclonazepam.

M Olivera1, C Martínez, G Gervasini, J A Carrillo, S Ramos, J Benítez, E García-Martin, J A G Agúndez.   

Abstract

We investigated the role of NAT2 on clonazepam acetylation, using transiently expressed human NAT2 alleles. The NAT25*B and the NAT2*6A variant alleles cause a 20 and 22-fold reduction in the Vmax, respectively. We conclude that NAT2 is responsible for 7-aminoclonazepam acetylation and that NAT2 gene polymorphisms impair such metabolic pathway.

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Year:  2007        PMID： 19356010     DOI： 10.2174/187231207779814283

Source DB:  PubMed          Journal:  Drug Metab Lett        ISSN： 1872-3128


  6 in total

1.  Identifying Metabolites of Meclonazepam by High-Resolution Mass Spectrometry Using Human Liver Microsomes, Hepatocytes, a Mouse Model, and Authentic Urine Samples.

Authors:  Svante Vikingsson; Ariane Wohlfarth; Mikael Andersson; Henrik Gréen; Markus Roman; Martin Josefsson; Fredrik C Kugelberg; Robert Kronstrand
Journal:  AAPS J       Date:  2017-01-13       Impact factor: 4.009

Review 2.  PharmGKB summary: very important pharmacogene information for N-acetyltransferase 2.

Authors:  Ellen M McDonagh; Sotiria Boukouvala; Eleni Aklillu; David W Hein; Russ B Altman; Teri E Klein
Journal:  Pharmacogenet Genomics       Date:  2014-08       Impact factor: 2.089

3.  Optimization of Clonazepam Therapy Adjusted to Patient's CYP3A Status and NAT2 Genotype.

Authors:  Katalin Tóth; Gábor Csukly; Dávid Sirok; Ales Belic; Ádám Kiss; Edit Háfra; Máté Déri; Ádám Menus; István Bitter; Katalin Monostory
Journal:  Int J Neuropsychopharmacol       Date:  2016-12-30       Impact factor: 5.176

4.  Functional Characterization of the Effects of N-acetyltransferase 2 Alleles on N-acetylation of Eight Drugs and Worldwide Distribution of Substrate-Specific Diversity.

Authors:  Koya Fukunaga; Ken Kato; Takuji Okusaka; Takeo Saito; Masashi Ikeda; Teruhiko Yoshida; Hitoshi Zembutsu; Nakao Iwata; Taisei Mushiroda
Journal:  Front Genet       Date:  2021-03-18       Impact factor: 4.599

Review 5.  Arylamine N-acetyltransferase acetylation polymorphisms: paradigm for pharmacogenomic-guided therapy- a focused review.

Authors:  David W Hein; Lori M Millner
Journal:  Expert Opin Drug Metab Toxicol       Date:  2020-11-03       Impact factor: 4.481

Review 6.  The Impact of Anti-Epileptic Drugs on Growth and Bone Metabolism.

Authors:  Hueng-Chuen Fan; Herng-Shen Lee; Kai-Ping Chang; Yi-Yen Lee; Hsin-Chuan Lai; Pi-Lien Hung; Hsiu-Fen Lee; Ching-Shiang Chi
Journal:  Int J Mol Sci       Date:  2016-08-01       Impact factor: 5.923
  6 in total

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