Literature DB >> 19355920

Apoptosis and oxidative stress-related diseases: the p66Shc connection.

Michela Pellegrini1, Cosima T Baldari.   

Abstract

p66Shc is the only known proapoptotic member of the Shc protein family of molecular adaptors. Through its redox activity, p66Shc oxidates cytochrome-c, leading to increased ROS production and, eventually, to apoptosis. p66Shc has been implicated in the control of oxidative stress and life span in mammals. In this review the multifaceted role of p66Shc in redox regulation will be discussed, with a focus on the mechanisms underlying p66Shc-dependent apoptosis and its role in oxidative stress-related diseases.

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Year:  2009        PMID： 19355920     DOI： 10.2174/156652409787847254

Source DB:  PubMed          Journal:  Curr Mol Med        ISSN： 1566-5240            Impact factor:   2.222


  13 in total

1.  Deletion of p66Shc in mice increases the frequency of size-change mutations in the lacZ transgene.

Authors:  Elena Beltrami; Antonella Ruggiero; Rita Busuttil; Enrica Migliaccio; Pier Giuseppe Pelicci; Jan Vijg; Marco Giorgio
Journal:  Aging Cell       Date:  2013-01-10       Impact factor: 9.304

2.  The redox enzyme p66Shc contributes to diabetes and ischemia-induced delay in cutaneous wound healing.

Authors:  Gian Paolo Fadini; Mattia Albiero; Lisa Menegazzo; Elisa Boscaro; Elisa Pagnin; Elisabetta Iori; Chiara Cosma; Annunziata Lapolla; Vittorio Pengo; Massimo Stendardo; Carlo Agostini; Pier Giuseppe Pelicci; Marco Giorgio; Angelo Avogaro
Journal:  Diabetes       Date:  2010-06-21       Impact factor: 9.461

Review 3.  Role of adaptor protein p66Shc in renal pathologies.

Authors:  Kevin D Wright; Alexander Staruschenko; Andrey Sorokin
Journal:  Am J Physiol Renal Physiol       Date:  2017-10-04

4.  Licoricidin improves neurological dysfunction after traumatic brain injury in mice via regulating FoxO3/Wnt/β-catenin pathway.

Authors:  Cai Liu; Dongqiang He; Qiming Zhao
Journal:  J Nat Med       Date:  2020-07-12       Impact factor: 2.343

5.  p66Shc signaling does not contribute to tubular damage induced by renal ischemia-reperfusion injury in rat.

Authors:  Bradley Miller; Kevin Regner; Andrey Sorokin
Journal:  Biochem Biophys Res Commun       Date:  2022-03-03       Impact factor: 3.575

6.  Diallyl trisulfide-induced prostate cancer cell death is associated with Akt/PKB dephosphorylation mediated by P-p66shc.

Authors:  Andzelika Borkowska; Alicja Sielicka-Dudzin; Anna Herman-Antosiewicz; Michal Wozniak; Donatella Fedeli; Giancarlo Falcioni; Jedrzej Antosiewicz
Journal:  Eur J Nutr       Date:  2011-10-22       Impact factor: 5.614

7.  Mitochondrial dysfunction and biogenesis: do ICU patients die from mitochondrial failure?

Authors:  Andrey V Kozlov; Soheyl Bahrami; Enrico Calzia; Peter Dungel; Lars Gille; Andrey V Kuznetsov; Jakob Troppmair
Journal:  Ann Intensive Care       Date:  2011-09-26       Impact factor: 6.925

8.  The synthetic inhibitor of fibroblast growth factor receptor PD166866 controls negatively the growth of tumor cells in culture.

Authors:  Gianfranco Risuleo; Marina Ciacciarelli; Mauro Castelli; Gaspare Galati
Journal:  J Exp Clin Cancer Res       Date:  2009-12-11

9.  Genetic inactivation of mitochondria-targeted redox enzyme p66ShcA preserves neuronal viability and mitochondrial integrity in response to oxidative challenges.

Authors:  Kimmy Su; Dennis Bourdette; Michael Forte
Journal:  Front Physiol       Date:  2012-07-20       Impact factor: 4.566

10.  Trichostatin A Modulates Angiotensin II-induced Vasoconstriction and Blood Pressure Via Inhibition of p66shc Activation.

Authors:  Gun Kang; Yu Ran Lee; Hee Kyoung Joo; Myoung Soo Park; Cuk-Seong Kim; Sunga Choi; Byeong Hwa Jeon
Journal:  Korean J Physiol Pharmacol       Date:  2015-08-20       Impact factor: 2.016
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