| Literature DB >> 1935249 |
E Llistosella1, A Codina, R Alvarez, R M Pujol, J M de Moragas.
Abstract
Four patients with colorectal cancer treated with tegafur (a fluoropyrimidine structurally similar to 5-fluorouracil) noted a macular, spotted hyperpigmentation limited to the palms, soles, nails, and glans penis. Histopathologic examination disclosed epidermal basal hyperpigmentation with a lentiginous pattern. Mucocutaneous lesions resolved spontaneously two months after treatment was discontinued. This peculiar phenomenon seems to represent a previously unreported side effect of this cytotoxic drug.Entities:
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Year: 1991 PMID： 1935249
Source DB: PubMed Journal: Cutis ISSN： 0011-4162