Literature DB >> 19352039

Identification of Ecl family genes that extend chronological lifespan in fission yeast.

Hokuto Ohtsuka1, Yuki Ogawa, Hiroyuki Mizuno, Satoka Mita, Hirofumi Aiba.   

Abstract

In fission yeast, we identified two genes, named ecl2+ and ecl3+, that are paralogous to ecl1+, which extends the chronological lifespan. Both ecl2+ and ecl3+ extend the chronological lifespan when overexpressed as ecl1+. ecl2+ and ecl3+ encode 84- and 89-amino acid polypeptides respectively that are not annotated in the current database. The Ecl2 protein is localized mainly in the nucleus, as Ecl1. These results suggest that ecl1+, ecl2+, and ecl3+ have overlapping functions in the regulation of chronological lifespan.

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Year:  2009        PMID： 19352039     DOI： 10.1271/bbb.80804

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  12 in total

1.  hsf1 (+) extends chronological lifespan through Ecl1 family genes in fission yeast.

Authors:  Hokuto Ohtsuka; Kenko Azuma; Hiroshi Murakami; Hirofumi Aiba
Journal:  Mol Genet Genomics       Date:  2010-11-12       Impact factor: 3.291

Review 2.  Aging and cell death in the other yeasts, Schizosaccharomyces pombe and Candida albicans.

Authors:  Su-Ju Lin; Nicanor Austriaco
Journal:  FEMS Yeast Res       Date:  2013-11-08       Impact factor: 2.796

3.  Posttranscriptional regulation of cell-cell interaction protein-encoding transcripts by Zfs1p in Schizosaccharomyces pombe.

Authors:  Melissa L Wells; Weichun Huang; Leping Li; Kevin E Gerrish; David C Fargo; Fatih Ozsolak; Perry J Blackshear
Journal:  Mol Cell Biol       Date:  2012-08-20       Impact factor: 4.272

4.  Ecl1 is a zinc-binding protein involved in the zinc-limitation-dependent extension of chronological life span in fission yeast.

Authors:  Takafumi Shimasaki; Hokuto Ohtsuka; Chikako Naito; Kenko Azuma; Takeshi Tenno; Hidekazu Hiroaki; Hiroshi Murakami; Hirofumi Aiba
Journal:  Mol Genet Genomics       Date:  2017-02-03       Impact factor: 3.291

5.  Pma1, a P-type proton ATPase, is a determinant of chronological life span in fission yeast.

Authors:  Hirokazu Ito; Tomoko Oshiro; Yasuyuki Fujita; Sachiko Kubota; Chikako Naito; Hokuto Ohtsuka; Hiroshi Murakami; Hirofumi Aiba
Journal:  J Biol Chem       Date:  2010-09-09       Impact factor: 5.157

Review 6.  Zinc sensing and regulation in yeast model systems.

Authors:  Stevin Wilson; Amanda J Bird
Journal:  Arch Biochem Biophys       Date:  2016-03-03       Impact factor: 4.013

7.  Sexual development of Schizosaccharomyces pombe is induced by zinc or iron limitation through Ecl1 family genes.

Authors:  Hokuto Ohtsuka; Maiko Ishida; Chikako Naito; Hiroshi Murakami; Hirofumi Aiba
Journal:  Mol Genet Genomics       Date:  2014-09-10       Impact factor: 3.291

8.  Screening for long-lived genes identifies Oga1, a guanine-quadruplex associated protein that affects the chronological lifespan of the fission yeast Schizosaccharomyces pombe.

Authors:  Hokuto Ohtsuka; Shingo Ogawa; Hideaki Kawamura; Erika Sakai; Keiko Ichinose; Hiroshi Murakami; Hirofumi Aiba
Journal:  Mol Genet Genomics       Date:  2013-05-03       Impact factor: 3.291

9.  Ecl1 is activated by the transcription factor Atf1 in response to H2O2 stress in Schizosaccharomyces pombe.

Authors:  Takafumi Shimasaki; Hokuto Ohtsuka; Chikako Naito; Hiroshi Murakami; Hirofumi Aiba
Journal:  Mol Genet Genomics       Date:  2014-04-03       Impact factor: 3.291

Review 10.  Extension of chronological lifespan in Schizosaccharomyces pombe.

Authors:  Hokuto Ohtsuka; Takafumi Shimasaki; Hirofumi Aiba
Journal:  Genes Cells       Date:  2021-05-12       Impact factor: 2.300
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