Yong-wei Fang1. 1. Shiyou Medical School of Hebei Medical University, Langfang 065000, China. fanyongwei.1969@yahoo.com.cn
Abstract
AIM: To study the correlation of expression of hTERT, c-myc and Ki-67 with the clinical pathological feature of hepatocellular carcinoma and explore the relationship among the three factors. METHODS: The expressions of hTERT, c-myc and Ki-67 in 37 cancer tissues and 5 normal tissues were assessed by immunohistochemical method. RESULTS: The positive rates of hTERT, c-myc and Ki-67 in the cancer tissue were higher than those in normal tissues (P<0.05). The expressions of hTERT, c-myc and Ki-67 had nothing to do with age, sex, metastasis and the volume of tumor(P>0.05). With histology stage reducing, the expression of hTERT, c-myc and Ki-67 increased obviously. There is no correlation between hTERT and c-myc(P>0.05), but it's positive correlation between hTERT and Ki-67(P<0.05). With the expression of Ki-67 increasing, hTERT and c-myc increased. CONCLUSION: The over-expression of hTERT, c-myc and Ki-67 may play a vital role in the progress of hepatocellular carcinoma developing. The expressions of three factors in hepatocellular carcinoma are closely associated.
AIM: To study the correlation of expression of hTERT, c-myc and Ki-67 with the clinical pathological feature of hepatocellular carcinoma and explore the relationship among the three factors. METHODS: The expressions of hTERT, c-myc and Ki-67 in 37 cancer tissues and 5 normal tissues were assessed by immunohistochemical method. RESULTS: The positive rates of hTERT, c-myc and Ki-67 in the cancer tissue were higher than those in normal tissues (P<0.05). The expressions of hTERT, c-myc and Ki-67 had nothing to do with age, sex, metastasis and the volume of tumor(P>0.05). With histology stage reducing, the expression of hTERT, c-myc and Ki-67 increased obviously. There is no correlation between hTERT and c-myc(P>0.05), but it's positive correlation between hTERT and Ki-67(P<0.05). With the expression of Ki-67 increasing, hTERT and c-myc increased. CONCLUSION: The over-expression of hTERT, c-myc and Ki-67 may play a vital role in the progress of hepatocellular carcinoma developing. The expressions of three factors in hepatocellular carcinoma are closely associated.