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Literature DB >> 19350258

Evaluation of the revised TNM classification in advanced laryngeal cancer.

G Psychogios¹, F Waldfahrer, A Bozzato, H Iro.

Abstract

The latest revision of the UICCs TNM classification in 2002 subdivided advanced laryngeal carcinoma into the subcategories T4a and T4b, in order to emphasise the poor prognosis and inoperability of the latter group. Our study aims at evaluating the prognostic relevance of this subclassification. This retrospective analysis includes 163 patients treated for advanced laryngeal carcinoma between 1980 and 2002. The disease-free 5-year-survival rates for patients suffering from T4a and T4b laryngeal carcinoma were 32.4 and 6.7%, respectively (P = 0.003). The T-category and free margins proved to be significant prognostic factors. The survival of patients suffering from T4a carcinoma proved to be independent of specific location and number of invaded structures. This study confirms the much poorer prognosis for patients suffering from T4b carcinoma and thus supports the modified TNM classification.

Entities: Disease Gene Species

Mesh：

Year: 2010 PMID： 19350258 DOI： 10.1007/s00405-009-0970-3

Source DB: PubMed Journal: Eur Arch Otorhinolaryngol ISSN： 0937-4477 Impact factor: 2.503

23 in total

1. Laryngeal cancer in the United States: changes in demographics, patterns of care, and survival.

Authors: Henry T Hoffman; Kimberly Porter; Lucy H Karnell; Jay S Cooper; Randall S Weber; Corey J Langer; Kie-Kian Ang; Greer Gay; Andrew Stewart; Robert A Robinson
Journal: Laryngoscope Date: 2006-09 Impact factor: 3.325

2. Single-cycle induction chemotherapy selects patients with advanced laryngeal cancer for combined chemoradiation: a new treatment paradigm.

Authors: Susan Urba; Gregory Wolf; Avraham Eisbruch; Francis Worden; Julia Lee; Carol Bradford; Theodoros Teknos; Douglas Chepeha; Mark Prince; Norman Hogikyan; Jeremy Taylor
Journal: J Clin Oncol Date: 2005-12-27 Impact factor: 44.544

3. Comparison of quality of life outcomes in laryngeal cancer patients following chemoradiation vs. total laryngectomy.

Authors: Maria M LoTempio; Kevin H Wang; Ahmed Sadeghi; Mark D Delacure; Guy F Juillard; Marilene B Wang
Journal: Otolaryngol Head Neck Surg Date: 2005-06 Impact factor: 3.497

4. [Prosthetic voice rehabilitation after laryngectomy. Failures and complications after previous radiation therapy].

Authors: P Kummer; M Chahoud; M Schuster; U Eysholdt; F Rosanowski
Journal: HNO Date: 2006-04 Impact factor: 1.284

Review 5. Postlaryngectomy voice rehabilitation: state of the art at the millennium.

Authors: Dale H Brown; Frans J M Hilgers; Jonathan C Irish; Alfons J M Balm
Journal: World J Surg Date: 2003-07 Impact factor: 3.352

6. Quality of life for patients following total laryngectomy vs chemoradiation for laryngeal preservation.

Authors: Ehab Hanna; Allen Sherman; David Cash; Dawn Adams; Emre Vural; Chun-Yang Fan; James Y Suen
Journal: Arch Otolaryngol Head Neck Surg Date: 2004-07

7. Induction chemotherapy with paclitaxel and cisplatin followed by radiotherapy for larynx organ preservation in advanced laryngeal and hypopharyngeal cancer offers moderate late toxicity outcome (DeLOS-I-trial).

Authors: Andreas Dietz; Volker Rudat; Jens Dreyhaupt; Maria Pritsch; Florian Hoppe; Rudolph Hagen; Leo Pfreundner; Ursula Schröder; Hans Eckel; Markus Hess; Michael Schröder; Petra Schneider; Bünzel Jens; Hans P Zenner; Jochen A Werner; Rita Engenhardt-Cabillic; Bernhard Vanselow; Peter Plinkert; Marcus Niewald; Thomas Kuhnt; Wilfried Budach; Michael Flentje
Journal: Eur Arch Otorhinolaryngol Date: 2008-10-30 Impact factor: 2.503

2. Expression and significance of hypoxia-inducible factor-1α and MDR1/P-glycoprotein in laryngeal carcinoma tissue and hypoxic Hep-2 cells.

Authors: Jin Xie; DA-Wei Li; Xin-Wei Chen; Fei Wang; Pin Dong
Journal: Oncol Lett Date: 2013-04-29 Impact factor: 2.967

2 in total

Evaluation of the revised TNM classification in advanced laryngeal cancer.

1. Laryngeal cancer in the United States: changes in demographics, patterns of care, and survival.

2. Single-cycle induction chemotherapy selects patients with advanced laryngeal cancer for combined chemoradiation: a new treatment paradigm.

3. Comparison of quality of life outcomes in laryngeal cancer patients following chemoradiation vs. total laryngectomy.

4. [Prosthetic voice rehabilitation after laryngectomy. Failures and complications after previous radiation therapy].

Review 5. Postlaryngectomy voice rehabilitation: state of the art at the millennium.

6. Quality of life for patients following total laryngectomy vs chemoradiation for laryngeal preservation.

7. Induction chemotherapy with paclitaxel and cisplatin followed by radiotherapy for larynx organ preservation in advanced laryngeal and hypopharyngeal cancer offers moderate late toxicity outcome (DeLOS-I-trial).

8. Quality of life correlates after surgery for laryngeal carcinoma.

9. Reconstruction with radial forearm flaps after ablative surgery for hypopharyngeal cancer.

10. Laser surgery of T1a glottic carcinomas; significance of resection margins.

1. Basics of tumor development and importance of human papilloma virus (HPV) for head and neck cancer.

2. Expression and significance of hypoxia-inducible factor-1α and MDR1/P-glycoprotein in laryngeal carcinoma tissue and hypoxic Hep-2 cells.