Literature DB >> 19350240

Hydroxyurea and hydroxamic acid derivatives as antitumor drugs.

Nina Saban1, Maro Bujak.   

Abstract

Hydroxyurea has been used for decades and it is still valuable for the treatment of some types of cancer. It inhibits ribonucleotide reductase (RNR) enzyme known to be crucial in the conversion of ribonucleotides into deoxyribonucleotides. However, nowadays the main focus has shifted to structurally similar hydroxamic acid derivatives that target specific enzymes involved in cancer progression such as histone deacetylases, matrix metalloproteinases and also RNR.

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Year:  2009        PMID： 19350240     DOI： 10.1007/s00280-009-0991-z

Source DB:  PubMed          Journal:  Cancer Chemother Pharmacol        ISSN： 0344-5704            Impact factor:   3.333


  32 in total

1.  Proton Coupled Electron Transfer and Redox Active Tyrosines: Structure and Function of the Tyrosyl Radicals in Ribonucleotide Reductase and Photosystem II.

Authors:  Bridgette A Barry; Jun Chen; James Keough; David Jenson; Adam Offenbacher; Cynthia Pagba
Journal:  J Phys Chem Lett       Date:  2012-02-08       Impact factor: 6.475

2.  Progesterone and DNA damage encourage uterine cell proliferation and decidualization through up-regulating ribonucleotide reductase 2 expression during early pregnancy in mice.

Authors:  Wei Lei; Xu-Hui Feng; Wen-Bo Deng; Hua Ni; Zhi-Rong Zhang; Bo Jia; Xin-Ling Yang; Tong-Song Wang; Ji-Long Liu; Ren-Wei Su; Xiao-Huan Liang; Qian-Rong Qi; Zeng-Ming Yang
Journal:  J Biol Chem       Date:  2012-03-08       Impact factor: 5.157

3.  Hyperkalaemia associated with hydroxyurea in a patient with polycythaemia vera.

Authors:  Srecko Marusic; Nives Gojo-Tomic; Vesna Bacic-Vrca; Velimir Bozikov
Journal:  Eur J Clin Pharmacol       Date:  2010-12-14       Impact factor: 2.953

4.  The Arabidopsis thaliana checkpoint kinase WEE1 protects against premature vascular differentiation during replication stress.

Authors:  Toon Cools; Anelia Iantcheva; Annika K Weimer; Shannah Boens; Naoki Takahashi; Sara Maes; Hilde Van den Daele; Gert Van Isterdael; Arp Schnittger; Lieven De Veylder
Journal:  Plant Cell       Date:  2011-04-15       Impact factor: 11.277

5.  The synthesis and evaluation of N1-(4-(2-[18F]-fluoroethyl)phenyl)-N8-hydroxyoctanediamide ([18F]-FESAHA), a PET radiotracer designed for the delineation of histone deacetylase expression in cancer.

Authors:  Brian M Zeglis; NagaVaraKishore Pillarsetty; Vadim Divilov; Ronald A Blasberg; Jason S Lewis
Journal:  Nucl Med Biol       Date:  2011-03-03       Impact factor: 2.408

6.  Hydroxyurea Treatment and Development of the Rat Cerebellum: Effects on the Neurogenetic Profiles and Settled Patterns of Purkinje Cells and Deep Cerebellar Nuclei Neurons.

Authors:  Joaquín Martí; M C Santa-Cruz; Roger Serra; José P Hervás
Journal:  Neurotox Res       Date:  2016-07-11       Impact factor: 3.911

7.  Developmental Injury to the Cerebellar Cortex Following Hydroxyurea Treatment in Early Postnatal Life: An Immunohistochemical and Electron Microscopic Study.

Authors:  Joaquín Martí; Vanesa Molina; M C Santa-Cruz; José P Hervás
Journal:  Neurotox Res       Date:  2016-09-06       Impact factor: 3.911

8.  Homocitrate synthase connects amino acid metabolism to chromatin functions through Esa1 and DNA damage.

Authors:  Erin M Scott; Lorraine Pillus
Journal:  Genes Dev       Date:  2010-09-01       Impact factor: 11.361

9.  Desferrioxamine inhibits protein tyrosine nitration: mechanisms and implications.

Authors:  Margaret A Adgent; Giuseppe L Squadrito; Carol A Ballinger; David M Krzywanski; Jack R Lancaster; Edward M Postlethwait
Journal:  Free Radic Biol Med       Date:  2012-06-15       Impact factor: 7.376

Review 10.  Where to Turn for Second-Line Cytoreduction After Hydroxyurea in Polycythemia Vera?

Authors:  Aziz Nazha; Aaron T Gerds
Journal:  Oncologist       Date:  2016-03-14
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