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Literature DB >> 19349977

Relief of itch by scratching: state-dependent inhibition of primate spinothalamic tract neurons.

Steve Davidson¹, Xijing Zhang, Sergey G Khasabov, Donald A Simone, Glenn J Giesler.

Abstract

Itch is relieved by scratching, but the neural mechanisms that are responsible for this are unknown. Spinothalamic tract (STT) neurons respond to itch-producing agents and transmit pruritic information to the brain. We observed that scratching the cutaneous receptive field of primate STT neurons produced inhibition during histamine-evoked activity but not during spontaneous activity or activity evoked by a painful stimulus, suggesting that scratching inhibits the transmission of itch in the spinal cord in a state-dependent manner.

Entities: Chemical Disease Gene Species

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Year: 2009 PMID： 19349977 PMCID： PMC3006451 DOI： 10.1038/nn.2292

Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884

14 in total

1. Spinothalamic lamina I neurons selectively sensitive to histamine: a central neural pathway for itch.

Authors: D Andrew; A D Craig
Journal: Nat Neurosci Date: 2001-01 Impact factor: 24.884

2. Attenuation of experimental pruritus and mechanically evoked dysesthesiae in an area of cutaneous allodynia.

Authors: S J Brull; P G Atanassoff; D G Silverman; J Zhang; R H Lamotte
Journal: Somatosens Mot Res Date: 1999 Impact factor: 1.111

Review 3. The neurobiology of itch.

Authors: Akihiko Ikoma; Martin Steinhoff; Sonja Ständer; Gil Yosipovitch; Martin Schmelz
Journal: Nat Rev Neurosci Date: 2006-07 Impact factor: 34.870

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Authors: D T GRAHAM; H GOODELL; H G WOLFF
Journal: J Clin Invest Date: 1951-01 Impact factor: 14.808

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Authors: Louise Ward; Ellen Wright; Stephen B McMahon
Journal: Pain Date: 1996-01 Impact factor: 6.961

6. The magnitude and duration of itch produced by intracutaneous injections of histamine.

Authors: D A Simone; J Y Ngeow; J Whitehouse; L Becerra-Cabal; G J Putterman; R H LaMotte
Journal: Somatosens Res Date: 1987

7. Responses of rat spinal dorsal horn neurons to intracutaneous microinjection of histamine, capsaicin, and other irritants.

Authors: E Carstens
Journal: J Neurophysiol Date: 1997-05 Impact factor: 2.714

Review 7. Trp channels and itch.

Authors: Shuohao Sun; Xinzhong Dong
Journal: Semin Immunopathol Date: 2015-09-18 Impact factor: 9.623

Review 8. Peripheral and Central Mechanisms of Itch.

Authors: Xintong Dong; Xinzhong Dong
Journal: Neuron Date: 2018-05-02 Impact factor: 17.173

Review 9. Itch mechanisms and circuits.

Authors: Liang Han; Xinzhong Dong
Journal: Annu Rev Biophys Date: 2014 Impact factor: 12.981

Review 10. Central Mechanisms of Itch.

Authors: Earl Carstens; Tasuku Akiyama
Journal: Curr Probl Dermatol Date: 2016-08-23

Relief of itch by scratching: state-dependent inhibition of primate spinothalamic tract neurons.

1. Spinothalamic lamina I neurons selectively sensitive to histamine: a central neural pathway for itch.

2. Attenuation of experimental pruritus and mechanically evoked dysesthesiae in an area of cutaneous allodynia.

Review 3. The neurobiology of itch.

4. Neural mechanisms involved in itch, itchy skin, and tickle sensations.

5. A comparison of the effects of noxious and innocuous counterstimuli on experimentally induced itch and pain.

6. The magnitude and duration of itch produced by intracutaneous injections of histamine.

7. Responses of rat spinal dorsal horn neurons to intracutaneous microinjection of histamine, capsaicin, and other irritants.

8. Imaging of central itch modulation in the human brain using positron emission tomography.

9. Chemical response pattern of different classes of C-nociceptors to pruritogens and algogens.

10. Comparison of responses of primate spinothalamic tract neurons to pruritic and algogenic stimuli.

1. Differences in peripheral endocannabinoid modulation of scratching behavior in facial vs. spinally-innervated skin.

2. Pruritus: an updated look at an old problem.

Review 3. Labeled lines meet and talk: population coding of somatic sensations.

4. VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch.

5. Pruriceptive spinothalamic tract neurons: physiological properties and projection targets in the primate.

6. Responses of neurons in the primary somatosensory cortex to itch- and pain-producing stimuli in rats.

Review 7. Trp channels and itch.

Review 8. Peripheral and Central Mechanisms of Itch.

Review 9. Itch mechanisms and circuits.

Review 10. Central Mechanisms of Itch.