| Literature DB >> 19349183 |
Florence Popowycz1, Cédric Schneider, Salvatore Debonis, Dimitrios A Skoufias, Frank Kozielski, Carlos M Galmarini, Benoît Joseph.
Abstract
Pyrazolo[1,5-a]-1,3,5-triazine myoseverin derivatives 1a-c were prepared from 4-(N-methyl-N-phenylamino)-2-methylsulfanylpyrazolo[1,5-a]-1,3,5-triazine 2. Their cytotoxic activity, inhibition of tubulin polymerization, and cell cycle effects were evaluated. Compounds 1a and 1c are potent tubulin inhibitors and displayed specific antiproliferative activity in colorectal cancer cell lines at micromolar concentrations.Entities:
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Year: 2009 PMID： 19349183 DOI： 10.1016/j.bmc.2009.03.007
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641