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Literature DB >> 19348706

Is GIGYF2 the defective gene at the PARK11 locus?

Abstract

The number of genes and loci for Parkinson's disease was expanded during 2008. Among the most interesting findings of the year was the nomination of GIGYF2 as the gene that is defective at the PARK11 locus and is a potentially frequent cause of typical Parkinson's disease. However, the optimism generated by the initial report has quickly been tempered by results obtained in the first wave of follow-up studies.

Entities: Disease Gene

Mesh：

Substances：

Year: 2009 PMID： 19348706 DOI： 10.1007/s11910-009-0028-3

Source DB: PubMed Journal: Curr Neurol Neurosci Rep ISSN： 1528-4042 Impact factor: 5.081

16 in total

1. Reported mutations in GIGYF2 are not a common cause of Parkinson's disease.

Authors: Carles Vilariño-Güell; Owen A Ross; Alexandra I Soto; Matthew J Farrer; Kristoffer Haugarvoll; Jan O Aasly; Ryan J Uitti; Zbigniew K Wszolek
Journal: Mov Disord Date: 2009-03-15 Impact factor: 10.338

2. High-resolution whole-genome association study of Parkinson disease.

Authors: Demetrius M Maraganore; Mariza de Andrade; Timothy G Lesnick; Kari J Strain; Matthew J Farrer; Walter A Rocca; P V Krishna Pant; Kelly A Frazer; David R Cox; Dennis G Ballinger
Journal: Am J Hum Genet Date: 2005-09-09 Impact factor: 11.025

3. PARK11 is not linked with Parkinson's disease in European families.

Authors: Jürgen Prestel; Manu Sharma; Petra Leitner; Alexander Zimprich; Jenny R Vaughan; Alexandra Dürr; Vincenzo Bonifati; Giuseppe De Michele; Hasmet A Hanagasi; Matthew Farrer; Anne Hofer; Friedrich Asmus; Giampiero Volpe; Giuseppe Meco; Alexis Brice; Nicholas W Wood; Bertram Müller-Myhsok; Thomas Gasser
Journal: Eur J Hum Genet Date: 2005-02 Impact factor: 4.246

4. Mutations in the GIGYF2 (TNRC15) gene at the PARK11 locus in familial Parkinson disease.

Authors: Corinne Lautier; Stefano Goldwurm; Alexandra Dürr; Barbara Giovannone; William G Tsiaras; Gianni Pezzoli; Alexis Brice; Robert J Smith
Journal: Am J Hum Genet Date: 2008-03-20 Impact factor: 11.025

5. Genome screen to identify susceptibility genes for Parkinson disease in a sample without parkin mutations.

Authors: Nathan Pankratz; William C Nichols; Sean K Uniacke; Cheryl Halter; Alice Rudolph; Cliff Shults; P Michael Conneally; Tatiana Foroud
Journal: Am J Hum Genet Date: 2002-06-07 Impact factor: 11.025

6. Lack of replication of association between GIGYF2 variants and Parkinson disease.

Authors: Jose Bras; Javier Simón-Sánchez; Monica Federoff; Ana Morgadinho; Cristina Januario; Maria Ribeiro; Luis Cunha; Catarina Oliveira; Andrew B Singleton
Journal: Hum Mol Genet Date: 2008-10-15 Impact factor: 6.150

7. A novel locus for dementia with Lewy bodies: a clinically and genetically heterogeneous disorder.

Authors: Veerle Bogaerts; Sebastiaan Engelborghs; Samir Kumar-Singh; Dirk Goossens; Barbara Pickut; Julie van der Zee; Kristel Sleegers; Karin Peeters; Jean-Jacques Martin; Jurgen Del-Favero; Thomas Gasser; Dennis W Dickson; Zbigniew K Wszolek; Peter P De Deyn; Jessie Theuns; Christine Van Broeckhoven
Journal: Brain Date: 2007-08-06 Impact factor: 13.501

Review 8. LRRK2 low-penetrance mutations (Gly2019Ser) and risk alleles (Gly2385Arg)-linking familial and sporadic Parkinson's disease.

Authors: Vincenzo Bonifati
Journal: Neurochem Res Date: 2007-04-18 Impact factor: 3.996

9. Haplotype analysis of the PARK 11 gene, GIGYF2, in sporadic Parkinson's disease.

Authors: Greg T Sutherland; Gerhard A Siebert; Jeremy R B Newman; Peter A Silburn; Richard S Boyle; John D O'Sullivan; George D Mellick
Journal: Mov Disord Date: 2009-02-15 Impact factor: 10.338

Review 10. Genetics of parkinsonism.

Authors: Vincenzo Bonifati
Journal: Parkinsonism Relat Disord Date: 2007 Impact factor: 4.891

1 in total

1. GIGYF2 gene disruption in mice results in neurodegeneration and altered insulin-like growth factor signaling.

Authors: Barbara Giovannone; William G Tsiaras; Suzanne de la Monte; Jan Klysik; Corinne Lautier; Galina Karashchuk; Stefano Goldwurm; Robert J Smith
Journal: Hum Mol Genet Date: 2009-09-10 Impact factor: 6.150

1 in total