Aihong Zhou1, Jianping Jia. 1. Department of Neurology, Xuanwu Hospital of the Capital Medical University, Beijing, China.
Abstract
OBJECTIVE: To screen for cognitive assessment for patients with vascular cognitive impairment (VCI) no dementia (V-CIND) from a set of cognitive measures. METHODS: Extensive neuropsychological tests covering five cognitive domains were performed on 80 V-CIND patients and 80 normal controls. The impaired domains in V-CIND were determined and the most discriminating tests were selected to form a comprehensive assessment. The discriminating validity of the individual tests and the comprehensive assessment were explored. RESULTS: Compared with the control group, five cognitive domains were all impaired in V-CIND group. World Health Organization-University of California-Los Angeles Auditory Verbal Learning Test (WHO-UCLA AVLT) immediate recall, Semantic Category Verbal Fluency Test (animal), Chinese version of the Wechsler Adult Intelligence Test (WAIS-RC) Digit Symbol Subtest, and Block Design Subtest were finally selected to form a comprehensive assessment tool, which achieved a sensitivity of 92.5% and a specificity of 98.8% in differentiating V-CIND patients from normal controls. Even in the subjects with Mini-Mental State Examination (MMSE) scores of 28 or above, high discriminative validity was also obtained. CONCLUSIONS: Our study revealed a multiple domain cognitive deficit in V-CIND patients. The comprehensive assessment tapping memory, executive functions, mental processing speed, and visuoconstructive skill may be potentially useful for an overall cognitive evaluation for V-CIND. Copyright (c) 2009 John Wiley & Sons, Ltd.
OBJECTIVE: To screen for cognitive assessment for patients with vascular cognitive impairment (VCI) no dementia (V-CIND) from a set of cognitive measures. METHODS: Extensive neuropsychological tests covering five cognitive domains were performed on 80 V-CINDpatients and 80 normal controls. The impaired domains in V-CIND were determined and the most discriminating tests were selected to form a comprehensive assessment. The discriminating validity of the individual tests and the comprehensive assessment were explored. RESULTS: Compared with the control group, five cognitive domains were all impaired in V-CIND group. World Health Organization-University of California-Los Angeles Auditory Verbal Learning Test (WHO-UCLA AVLT) immediate recall, Semantic Category Verbal Fluency Test (animal), Chinese version of the Wechsler Adult Intelligence Test (WAIS-RC) Digit Symbol Subtest, and Block Design Subtest were finally selected to form a comprehensive assessment tool, which achieved a sensitivity of 92.5% and a specificity of 98.8% in differentiating V-CINDpatients from normal controls. Even in the subjects with Mini-Mental State Examination (MMSE) scores of 28 or above, high discriminative validity was also obtained. CONCLUSIONS: Our study revealed a multiple domain cognitive deficit in V-CINDpatients. The comprehensive assessment tapping memory, executive functions, mental processing speed, and visuoconstructive skill may be potentially useful for an overall cognitive evaluation for V-CIND. Copyright (c) 2009 John Wiley & Sons, Ltd.
Authors: Danelle Rolle-McFarland; Yingzi Liu; Farshad Mostafaei; S Elizabeth Zauber; Yuanzhong Zhou; Yan Li; Qiyuan Fan; Wei Zheng; Linda H Nie; Ellen M Wells Journal: Sci Total Environ Date: 2019-02-21 Impact factor: 7.963
Authors: Alar Kaskikallio; Mira Karrasch; Juha Koikkalainen; Jyrki Lötjönen; Juha O Rinne; Terhi Tuokkola; Riitta Parkkola; Petra Grönholm-Nyman Journal: Front Aging Neurosci Date: 2021-05-06 Impact factor: 5.750