Literature DB >> 19347799

HIV-1-inhibiting activity of the essential oil of Ridolfia segetum and Oenanthe crocata.

Carlo Bicchi1, Patrizia Rubiolo, Mauro Ballero, Cinzia Sanna, Maura Matteodo, Francesca Esposito, Luca Zinzula, Enzo Tramontano.   

Abstract

The essential oils of Ridolfia segetum (L.) Moris and Oenanthe crocata L. (Apiaceae), collected in Sardinia (Italy), have been assayed for two enzyme-associated activities of the HIV-1 reverse transcriptase (RT): RNA-dependent DNA polymerase (RDDP) activity and ribonuclease H (RNase H) activity. In biochemical assays, the essential oils inhibited HIV-1 RT RDDP activity in a dose-dependent manner, while they were inactive towards RNase H activity. Furthermore, the oils were cytotoxic towards K (562) cell replication. GC-MS analysis of the essential oils obtained by steam distillation of the aerial parts showed that the main components of R. segetum were alpha-phellandrene, alpha-terpinolene, beta-phellandrene, and dillapiol and those of O. crocata were sabinene, TRANS-beta-ocimene, CIS-beta-ocimene, and beta-pinene. Georg Thieme Verlag KG Stuttgart, New York.

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Year:  2009        PMID： 19347799     DOI： 10.1055/s-0029-1185546

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  9 in total

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  9 in total

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