Literature DB >> 19346374

Resistance-mediating polymorphisms in Plasmodium falciparum infections in Kinshasa, Democratic Republic of the Congo.

Linda Mobula1, Bruce Lilley, Antoinette K Tshefu, Philip J Rosenthal.   

Abstract

Genetic polymorphisms in Plasmodium falciparum are associated with resistance to a number of drugs, but data on their prevalence are limited from many areas. We explored the prevalence of key polymorphisms in patients presenting with malaria in Kinshasa. Prevalences of pfcrt K76T; pfmdr1 N86Y; pfdhfr N51I, C59R, and S108N; and pfdhps A437G were well above 50% and of pfmdr1 Y184F, N1042D, and D1246Y; pfdhfr I164L; and pfdhps K540E were low. These results suggest an intermediate level of resistance to aminoquinoline and antifolate antimalarials in Kinshasa compared with other areas of Africa.

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Year:  2009        PMID： 19346374

Source DB:  PubMed          Journal:  Am J Trop Med Hyg        ISSN： 0002-9637            Impact factor:   2.345


  14 in total

1.  On the diversity of malaria parasites in African apes and the origin of Plasmodium falciparum from Bonobos.

Authors:  Sabrina Krief; Ananias A Escalante; M Andreina Pacheco; Lawrence Mugisha; Claudine André; Michel Halbwax; Anne Fischer; Jean-Michel Krief; John M Kasenene; Mike Crandfield; Omar E Cornejo; Jean-Marc Chavatte; Clara Lin; Franck Letourneur; Anne Charlotte Grüner; Thomas F McCutchan; Laurent Rénia; Georges Snounou
Journal:  PLoS Pathog       Date:  2010-02-12       Impact factor: 6.823

2.  A cross-sectional survey of Plasmodium falciparum pfcrt mutant haplotypes in the Democratic Republic of Congo.

Authors:  Alejandro L Antonia; Steve M Taylor; Mark Janko; Michael Emch; Antoinette K Tshefu; Steven R Meshnick
Journal:  Am J Trop Med Hyg       Date:  2014-04-14       Impact factor: 2.345

3.  Various pfcrt and pfmdr1 genotypes of Plasmodium falciparum cocirculate with P. malariae, P. ovale spp., and P. vivax in northern Angola.

Authors:  Cláudia Fançony; Dina Gamboa; Yuri Sebastião; Rachel Hallett; Colin Sutherland; José Carlos Sousa-Figueiredo; Susana Vaz Nery
Journal:  Antimicrob Agents Chemother       Date:  2012-07-30       Impact factor: 5.191

4.  Characterization of pfmdr1, pfcrt, pfK13, pfubp1, and pfap2mu in Travelers Returning from Africa with Plasmodium falciparum Infections Reported in China from 2014 to 2018.

Authors:  Jun Feng; Dongmei Xu; Xiangli Kong; Kangming Lin; He Yan; Xinyu Feng; Hong Tu; Zhigui Xia
Journal:  Antimicrob Agents Chemother       Date:  2021-06-17       Impact factor: 5.191

5.  Five years of antimalarial resistance marker surveillance in Gaza Province, Mozambique, following artemisinin-based combination therapy roll out.

Authors:  Jaishree Raman; Katya Mauff; Pedro Muianga; Abdul Mussa; Rajendra Maharaj; Karen I Barnes
Journal:  PLoS One       Date:  2011-10-14       Impact factor: 3.240

Review 6.  Falciparum malaria molecular drug resistance in the Democratic Republic of Congo: a systematic review.

Authors:  Dieudonné Makaba Mvumbi; Jean-Marie Kayembe; Hippolyte Situakibanza; Thierry L Bobanga; Célestin N Nsibu; Georges L Mvumbi; Pierrette Melin; Patrick De Mol; Marie-Pierre Hayette
Journal:  Malar J       Date:  2015-09-17       Impact factor: 2.979

7.  Assessment of pfcrt 72-76 haplotypes eight years after chloroquine withdrawal in Kinshasa, Democratic Republic of Congo.

Authors:  Dieudonné Makaba Mvumbi; Raphael Boreux; Rosalie Sacheli; Mvumbi Lelo; Bobanga Lengu; Situakibanza Nani-Tuma; Pierrette Melin; Kayembe Ntumba; Kalala Lunganza; Patrick DeMol; Marie-Pierre Hayette
Journal:  Malar J       Date:  2013-12-20       Impact factor: 2.979

8.  Randomized comparison of the efficacies and tolerabilities of three artemisinin-based combination treatments for children with acute Plasmodium falciparum malaria in the Democratic Republic of the Congo.

Authors:  M A Onyamboko; C I Fanello; K Wongsaen; J Tarning; P Y Cheah; K A Tshefu; A M Dondorp; F Nosten; N J White; N P J Day
Journal:  Antimicrob Agents Chemother       Date:  2014-07-07       Impact factor: 5.191

9.  High School Students Are a Target Group for Fight against Self-Medication with Antimalarial Drugs: A Pilot Study in University of Kinshasa, Democratic Republic of Congo.

Authors:  Ramsès Kabongo Kamitalu; Michel Ntetani Aloni
Journal:  J Trop Med       Date:  2016-06-02

10.  Evaluation of artemether-lumefantrine efficacy in the treatment of uncomplicated malaria and its association with pfmdr1, pfatpase6 and K13-propeller polymorphisms in Luanda, Angola.

Authors:  Kinanga Kiaco; Joana Teixeira; Marta Machado; Virgílio do Rosário; Dinora Lopes
Journal:  Malar J       Date:  2015-12-16       Impact factor: 2.979
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