| Literature DB >> 19346165 |
Ann Pettersson1, Gunnar Nylund, Amir Khorram-Manesh, Svante Nordgren, Dick S Delbro.
Abstract
The secreted mammalian Ly-6/urokinase plasminogen activator receptor-related protein-1 (SLURP-1) is an endogenous ligand at the alpha 7 subunit of the nicotinic acetylcholine receptor (nAChR). SLURP-1 has anti-tumourigenic properties. In the current study, we demonstrate that the challenge of HT-29 human colon cancer cells with nicotine for 24 h to increase cell growth via the alpha 7nAChRs, caused a marked reduction of the protein expression of SLURP-1. We suggest that there is an interplay between acetylcholine and SLURP-1 in the HT-29 cells, both molecules serving as autocrine growth controlling ligands at the alpha 7nAChR, where acetylcholine regulates the release of SLURP-1.Entities:
Mesh：
Substances：
Year: 2009 PMID： 19346165 DOI： 10.1016/j.autneu.2009.03.002
Source DB: PubMed Journal: Auton Neurosci ISSN： 1566-0702 Impact factor: 3.145