BACKGROUND AND AIM: Weight gain is associated with a decline in insulin sensitivity and a compensatory increase in insulin secretion. IGF-1 is a plausible candidate to explain these divergent phenomena. In this cross-sectional study, we analyzed the relationship between IGF-1 levels, insulin sensitivity and secretion in 110 nondiabetic subjects with a wide range of BMI to verify this hypothesis. METHODS AND RESULTS: Subjects underwent OGTT, IVGTT and euglycemic-hyperinsulinemic clamp. HOMA-beta, IVGTT-derived and OGTT-derived indexes for first-phase and second-phase insulin secretion were higher in obese as compared with overweight and normal-weight groups, while glucose disposal was lower. IGF-1 levels were negatively correlated with IVGTT-derived and OGTT-derived indexes first-phase and second-phase insulin secretion, and positively correlated with glucose disposal. These correlations were no longer significant after adjustment for BMI. In a multivariate analysis, the variables associated with glucose disposal were IGF-1, age, triglycerides, and 2-h post-load glucose accounting for 23.4% of its variation. When BMI was entered into the model, the variables associated with glucose disposal were triglycerides, 2-h post-load glucose and BMI accounting for 27.2% of variation. In a multivariate analysis, the only variable associated with IVGTT-derived first-phase and second-phase insulin secretion was IGF-1 accounting for 10.4% and 15.1% of variation, respectively. When BMI was entered into the model, it became the only variable associated with both first-phase and second-phase insulin secretion accounting for 25.7% and 37.6% of variation, respectively. CONCLUSION: These data suggest that progressive reduction in IGF-1 levels may be involved in obesity-related changes in both insulin sensitivity and secretion.
BACKGROUND AND AIM: Weight gain is associated with a decline in insulin sensitivity and a compensatory increase in insulin secretion. IGF-1 is a plausible candidate to explain these divergent phenomena. In this cross-sectional study, we analyzed the relationship between IGF-1 levels, insulin sensitivity and secretion in 110 nondiabetic subjects with a wide range of BMI to verify this hypothesis. METHODS AND RESULTS: Subjects underwent OGTT, IVGTT and euglycemic-hyperinsulinemic clamp. HOMA-beta, IVGTT-derived and OGTT-derived indexes for first-phase and second-phase insulin secretion were higher in obese as compared with overweight and normal-weight groups, while glucose disposal was lower. IGF-1 levels were negatively correlated with IVGTT-derived and OGTT-derived indexes first-phase and second-phase insulin secretion, and positively correlated with glucose disposal. These correlations were no longer significant after adjustment for BMI. In a multivariate analysis, the variables associated with glucose disposal were IGF-1, age, triglycerides, and 2-h post-load glucose accounting for 23.4% of its variation. When BMI was entered into the model, the variables associated with glucose disposal were triglycerides, 2-h post-load glucose and BMI accounting for 27.2% of variation. In a multivariate analysis, the only variable associated with IVGTT-derived first-phase and second-phase insulin secretion was IGF-1 accounting for 10.4% and 15.1% of variation, respectively. When BMI was entered into the model, it became the only variable associated with both first-phase and second-phase insulin secretion accounting for 25.7% and 37.6% of variation, respectively. CONCLUSION: These data suggest that progressive reduction in IGF-1 levels may be involved in obesity-related changes in both insulin sensitivity and secretion.
Authors: Daniela A Rubin; Hoang N Pham; Eric S Adams; Andrew R Tutor; Anthony C Hackney; Jared W Coburn; Daniel A Judelson Journal: Eur J Appl Physiol Date: 2015-01-30 Impact factor: 3.078
Authors: Su Yon Jung; Stephen D Hursting; Michele Guindani; Mara Z Vitolins; Electra Paskett; Shine Chang Journal: Cancer Epidemiol Biomarkers Prev Date: 2013-12-20 Impact factor: 4.254
Authors: Ziad S Mahmassani; Paul T Reidy; Alec I McKenzie; Jonathan J Petrocelli; O'Connor Matthews; Naomi M de Hart; Patrick J Ferrara; Ryan M O'Connell; Katsuhiko Funai; Micah J Drummond Journal: Obesity (Silver Spring) Date: 2020-02-28 Impact factor: 5.002
Authors: Ajay Thankamony; Donatella Capalbo; M Loredana Marcovecchio; Alison Sleigh; Sine Wanda Jørgensen; Nathan R Hill; Katrin Mooslehner; Giles S H Yeo; Les Bluck; Anders Juul; Allan Vaag; David B Dunger Journal: J Clin Endocrinol Metab Date: 2014-03-11 Impact factor: 5.958
Authors: Maria A Marini; Elena Succurro; Ersilia Castaldo; Sabrina Cufone; Franco Arturi; Angela Sciacqua; Renato Lauro; Marta L Hribal; Francesco Perticone; Giorgio Sesti Journal: Diabetes Care Date: 2012-03-07 Impact factor: 19.112
Authors: Maria A Marini; Elena Succurro; Simona Frontoni; Simona Mastroianni; Franco Arturi; Angela Sciacqua; Renato Lauro; Marta L Hribal; Francesco Perticone; Giorgio Sesti Journal: Diabetes Care Date: 2012-02-22 Impact factor: 19.112
Authors: Gaia Chiara Mannino; Annalisa Greco; Carlo De Lorenzo; Francesco Andreozzi; Maria A Marini; Francesco Perticone; Giorgio Sesti Journal: PLoS One Date: 2013-12-31 Impact factor: 3.240