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Literature DB >> 1934589

The H3 anti-phospholipid idiotype is found in patients with systemic lupus erythematosus (SLE) but not in patients with syphilis.

A Hohmann¹, R Comacchio, V Boswarva, M Sutjita, J Bradley.

Abstract

The human H3 idiotype, defined by a mouse monoclonal antibody S2.9, is commonly found in patients with SLE where it is correlated with the amount of anti-cardiolipin antibodies. No correlation between the amount of anti-cardiolipin antibody and the H3 idiotype is found in patients with syphilis. Using the S2.9 antibody, serum from each of 10 patients with SLE and eight patients with syphilis was separated into H3-bearing and H3-negative fractions. Comparison of the partition of anti-cardiolipin antibody in these two groups of patients revealed that much of the anti-cardiolipin antibody (44-91%) was found in the H3+ fraction in patients with SLE; in patients with syphilis, virtually none of the anti-cardiolipin antibody was H3+. In patients with SLE, the H3+ fraction contained both IgG and IgM and antibodies of both kappa and lambda light chains. The H3+ fraction was polyspecific and frequently reacted with dsDNA.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1991 PMID： 1934589 PMCID： PMC1554133 DOI： 10.1111/j.1365-2249.1991.tb05797.x

Source DB: PubMed Journal: Clin Exp Immunol ISSN： 0009-9104 Impact factor: 4.330

23 in total

1. Anticardiolipin response in acute infections.

Authors: O Vaarala; T Palosuo; M Kleemola; K Aho
Journal: Clin Immunol Immunopathol Date: 1986-10

2. Is anticardiolipin activity a cross-reaction of anti-DNA or a separate entity?

Authors: R J Smeenk; W A Lucassen; T J Swaak
Journal: Arthritis Rheum Date: 1987-06

Review 3. Anti-phospholipid antibodies.

Authors: E N Harris; A E Gharavi; G R Hughes
Journal: Clin Rheum Dis Date: 1985-12

4. Immunological specificity and mechanism of action of IgG lupus anticoagulants.

Authors: V Pengo; P Thiagarajan; S S Shapiro; M J Heine
Journal: Blood Date: 1987-07 Impact factor: 22.113

5. Anticardiolipin antibodies: isotype distribution and phospholipid specificity.

Authors: A E Gharavi; E N Harris; R A Asherson; G R Hughes
Journal: Ann Rheum Dis Date: 1987-01 Impact factor: 19.103

6. A common anti-DNA idiotype in sera of patients with active pulmonary tuberculosis.

Authors: O Sela; A el-Roeiy; D A Isenberg; R C Kennedy; C B Colaco; J Pinkhas; Y Shoenfeld
Journal: Arthritis Rheum Date: 1987-01

7. Evaluation of the cross-reaction between anti-DNA and anti-cardiolipin antibodies in SLE and experimental animals.

Authors: D Eilat; A Y Zlotnick; R Fischel
Journal: Clin Exp Immunol Date: 1986-08 Impact factor: 4.330

8. Idiotypic markers of polyclonal B cell activation. Public idiotypes shared by monoclonal antibodies derived from patients with systemic lupus erythematosus or leprosy.

Authors: C Mackworth-Young; J Sabbaga; R S Schwartz
Journal: J Clin Invest Date: 1987-02 Impact factor: 14.808

9. The lupus anticoagulant. A disease marker in antinuclear antibody negative lupus that is cross-reactive with autoantibodies to double-stranded DNA.

Authors: C B Colaco; K B Elkon
Journal: Arthritis Rheum Date: 1985-01

5. Phospholipid binding specificities and idiotype expression of hybridoma derived monoclonal autoantibodies from splenic cells of patients with systemic lupus erythematosus.

Authors: C T Ravirajan; I Harmer; T McNally; A Hohmann; C G Mackworth-Young; D A Isenberg
Journal: Ann Rheum Dis Date: 1995-06 Impact factor: 19.103

5 in total

The H3 anti-phospholipid idiotype is found in patients with systemic lupus erythematosus (SLE) but not in patients with syphilis.

1. Anticardiolipin response in acute infections.

2. Is anticardiolipin activity a cross-reaction of anti-DNA or a separate entity?

Review 3. Anti-phospholipid antibodies.

4. Immunological specificity and mechanism of action of IgG lupus anticoagulants.

5. Anticardiolipin antibodies: isotype distribution and phospholipid specificity.

6. A common anti-DNA idiotype in sera of patients with active pulmonary tuberculosis.

7. Evaluation of the cross-reaction between anti-DNA and anti-cardiolipin antibodies in SLE and experimental animals.

8. Idiotypic markers of polyclonal B cell activation. Public idiotypes shared by monoclonal antibodies derived from patients with systemic lupus erythematosus or leprosy.

9. The lupus anticoagulant. A disease marker in antinuclear antibody negative lupus that is cross-reactive with autoantibodies to double-stranded DNA.

10. Monoclonal anti-cardiolipin antibodies bind to DNA.

1. Anti-DNA and antiphospholipid antibodies in IVIG preparations: in vivo study in naive mice.

2. Anti-idiotype immunomodulation of experimental anti-phospholipid syndrome via effect on Th1/Th2 expression.

3. Pathogenic natural anti-cardiolipin antibodies: the experience from monoclonal gammopathy.

4. Pathogenic serum IgG anticardiolipin antibodies and the idiotypic network.

5. Phospholipid binding specificities and idiotype expression of hybridoma derived monoclonal autoantibodies from splenic cells of patients with systemic lupus erythematosus.