| Literature DB >> 19345255 |
M J Park1, K S Gwak, I Yang, K W Kim, E B Jeung, J W Chang, I G Choi.
Abstract
The antifungal effects of citral, eugenol, nerolidol and alpha-terpineol on Trichophyton mentagrophytes were investigated. Citral over 0.1 mg/ml strongly inhibited the hyphal growth of T. mentagrophytes, and the antifungal activity of alpha-terpineol was less effective. The morphological changes of the fungus exposed to the terpenes were observed by electron microscopy. The hyphae were distorted and collapsed at 0.2, 0.4 and 1 mg/ml of eugenol, nerolidol and alpha-terpineol respectively, and cell membrane and organelles were irreversibly damaged at 0.2 mg/ml citral. These suggested that four terpenes possess antifungal activity against T. mentagrophytes, and the activity might lead to irreversible cellular disruption.Entities:
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Year: 2009 PMID： 19345255 DOI： 10.1016/j.fitote.2009.03.007
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882