| Literature DB >> 19345077 |
Essam Abdel-Sattar1, Naglaa G Shehab, Chikara Ichino, Hiroaki Kiyohara, Aki Ishiyama, Kazuhiko Otoguro, Satoshi Omura, Haruki Yamada.
Abstract
Pregnane glycosides previously isolated from genus Caralluma (C. Penicillata, C. tuberculata and C. russelliana) were tested for their antitrypanosomal activity. Penicilloside E showed the highest antitrypanosomal activity (IC(50) 1.01 microg/ml) followed by caratuberside C (IC(50) 1.85 microg/ml), which exhibited the highest selectivity index (SI 12.04). It was noticed that acylation is required for the antitrypanosomal activity while glycosylation at C-20 has no significant effect on the activity.Entities:
Mesh：
Substances：
Year: 2009 PMID： 19345077 DOI： 10.1016/j.phymed.2009.02.009
Source DB: PubMed Journal: Phytomedicine ISSN： 0944-7113 Impact factor: 5.340