Literature DB >> 19345040

Loss of vancomycin bactericidal activity against accessory gene regulator (agr) dysfunctional Staphylococcus aureus under conditions of high bacterial density.

Brian T Tsuji1, Yoriko Harigaya, Alan J Lesse, George Sakoulas, Joseph M Mylotte.   

Abstract

The impact of accessory gene regulator (agr) dysfunction and high bacterial density on vancomycin killing and resistance was evaluated among 10 clinical methicillin-resistant Staphylococcus aureus bloodstream isolates using time kill experiments. Under conditions of high inocula and agr dysfunction, vancomycin activity was markedly attenuated, amplifying resistant mutants by 72 h.

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Year:  2009        PMID： 19345040     DOI： 10.1016/j.diagmicrobio.2009.01.028

Source DB:  PubMed          Journal:  Diagn Microbiol Infect Dis        ISSN： 0732-8893            Impact factor:   2.803


  12 in total

1.  Preferential emergence of reduced vancomycin susceptibility in health care-associated methicillin-resistant Staphylococcus aureus isolates during continuous-infusion vancomycin therapy in an in vitro dynamic model.

Authors:  Sheryl Zelenitsky; Noha Alkurdi; Zhanni Weber; Robert Ariano; George Zhanel
Journal:  Antimicrob Agents Chemother       Date:  2011-04-18       Impact factor: 5.191

2.  Predictors of agr dysfunction in methicillin-resistant Staphylococcus aureus (MRSA) isolates among patients with MRSA bloodstream infections.

Authors:  Jill M Butterfield; Brian T Tsuji; Jack Brown; Elizabeth Dodds Ashley; Dwight Hardy; Kristen Brown; Alan Forrest; Thomas P Lodise
Journal:  Antimicrob Agents Chemother       Date:  2011-09-19       Impact factor: 5.191

3.  Combinatorial Pharmacodynamics of Ceftolozane-Tazobactam against Genotypically Defined β-Lactamase-Producing Escherichia coli: Insights into the Pharmacokinetics/Pharmacodynamics of β-Lactam-β-Lactamase Inhibitor Combinations.

Authors:  Rachel L Soon; Justin R Lenhard; Zackery P Bulman; Patricia N Holden; Pamela Kelchlin; Judith N Steenbergen; Lawrence V Friedrich; Alan Forrest; Brian T Tsuji
Journal:  Antimicrob Agents Chemother       Date:  2016-03-25       Impact factor: 5.191

4.  Increased mortality with accessory gene regulator (agr) dysfunction in Staphylococcus aureus among bacteremic patients.

Authors:  Marin L Schweizer; Jon P Furuno; George Sakoulas; J Kristie Johnson; Anthony D Harris; Michelle D Shardell; Jessina C McGregor; Kerri A Thom; Eli N Perencevich
Journal:  Antimicrob Agents Chemother       Date:  2010-12-20       Impact factor: 5.191

5.  Front-loaded linezolid regimens result in increased killing and suppression of the accessory gene regulator system of Staphylococcus aureus.

Authors:  Brian T Tsuji; Tanya Brown; Ridhi Parasrampuria; Daniel A Brazeau; Alan Forrest; Pamela A Kelchlin; Patricia N Holden; Charles A Peloquin; Debra Hanna; Jurgen B Bulitta
Journal:  Antimicrob Agents Chemother       Date:  2012-04-23       Impact factor: 5.191

Review 6.  Predictors of mortality in Staphylococcus aureus Bacteremia.

Authors:  Sebastian J van Hal; Slade O Jensen; Vikram L Vaska; Björn A Espedido; David L Paterson; Iain B Gosbell
Journal:  Clin Microbiol Rev       Date:  2012-04       Impact factor: 26.132

7.  Accessory gene regulator (agr) dysfunction in Staphylococcus aureus bloodstream isolates from South Korean patients.

Authors:  Yong Pil Chong; Eun Sil Kim; Su-Jin Park; Ki-Ho Park; Tark Kim; Mi-Na Kim; Sung-Han Kim; Sang-Oh Lee; Sang-Ho Choi; Jun Hee Woo; Jin-Yong Jeong; Yang Soo Kim
Journal:  Antimicrob Agents Chemother       Date:  2012-12-17       Impact factor: 5.191

Review 8.  Reduced vancomycin susceptibility in Staphylococcus aureus, including vancomycin-intermediate and heterogeneous vancomycin-intermediate strains: resistance mechanisms, laboratory detection, and clinical implications.

Authors:  Benjamin P Howden; John K Davies; Paul D R Johnson; Timothy P Stinear; M Lindsay Grayson
Journal:  Clin Microbiol Rev       Date:  2010-01       Impact factor: 26.132

9.  The DUF59 Containing Protein SufT Is Involved in the Maturation of Iron-Sulfur (FeS) Proteins during Conditions of High FeS Cofactor Demand in Staphylococcus aureus.

Authors:  Ameya A Mashruwala; Shiven Bhatt; Saroj Poudel; Eric S Boyd; Jeffrey M Boyd
Journal:  PLoS Genet       Date:  2016-08-12       Impact factor: 5.917

10.  Clinical outcomes and molecular typing of heterogenous vancomycin-intermediate Staphylococcus aureus bacteremia in patients in intensive care units.

Authors:  Han-Chung Hu; Kuo-Chin Kao; Li-Chung Chiu; Chih-Hao Chang; Chen-Yiu Hung; Li-Fu Li; Tsui-Ping Liu; Lee-Chung Lin; Ning-Hung Chen; Chung-Chi Huang; Cheng-Ta Yang; Jang-Jih Lu
Journal:  BMC Infect Dis       Date:  2015-10-23       Impact factor: 3.090
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