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Literature DB >> 193448

Immunological disorders and malignancies in five young brothers.

D T Purtilo, J A Riordan, D Deflorio, J P Yang, P Sun, G Vawter.

Abstract

Five brothers of from 6 to 18 years of age experienced immunological or neoplastic disorders during an 8-year interval. 2 boys succumbed to glioblastoma multiforme, another to metastatic carcinoma, and the 2 surviving brothers had a histiocytic lymphoma and idiopathic thrombocytopenia purpura, respectively. The mother of the boys was healthy, but her twin sister died in utero of birth defects. We suggest that an intrinsic cellular defect inherited from their mother rendered the boys vulnerable to oncogenesis.

Entities: Disease Species

Mesh：

Year: 1977 PMID： 193448 PMCID： PMC1544651 DOI： 10.1136/adc.52.4.310

Source DB: PubMed Journal: Arch Dis Child ISSN： 0003-9888 Impact factor: 3.791

11 in total

Review 4. Turcot's syndrome and familial adenomatous polyposis associated with brain tumor: review of related literature.

Authors: H Itoh; K Hirata; K Ohsato
Journal: Int J Colorectal Dis Date: 1993-07 Impact factor: 2.571

4 in total

Immunological disorders and malignancies in five young brothers.

Review 1. Another look at immunologic surveillance.

2. Transmission of retinoblastoma by nonaffected members of a family. A family history.

3. Lymphoreticular malignancies and immunologic abnormalities in a sibship.

4. Genetic implications of familial brain tumors.

5. Deaths from childhood cancer in sibs.

6. Six families prone to ovarian cancer.

7. Common variable immunodeficiency, Hodgkin's disease, and other malignancies in a Newfoundland family.

8. Childhood cancer in sibs.

9. X-linked recessive progressive combined variable immunodeficiency (Duncan's disease).

10. Familial neuroblastoma. Report of a kindred with multiple disorders, including neuroblastomas in four siblings.

Review 1. Genetics of neoplasia--impact of ecogenetics on oncogenesis. A review.

2. Synchronous occurrence of glioblastoma multiforme in a husband and wife.

3. Familial glioma: occurrence within the "familial cancer syndrome" and systemic malformations.

Review 4. Turcot's syndrome and familial adenomatous polyposis associated with brain tumor: review of related literature.