Literature DB >> 19344713

Expression of PDGF receptor-alpha in corneal myofibroblasts in situ.

Harmeet Kaur, Shyam S Chaurasia, Vandana Agrawal, Steven E Wilson.   

Abstract

The purpose of this study was to investigate the expression of platelet-derived growth factor receptor-alpha (PDGFR-alpha) in the myofibroblasts of corneas with stromal haze. Central corneal sections from rabbit eyes that had -9 diopter PRK were analyzed by immunocytochemistry (IHC) for the expression of PDGFR-alpha at 4 week after surgery. PDGFR-alpha was expressed immediately beneath the epithelial basement membrane in the anterior stroma. Double IHC studies revealed the expression of PDGFR-alpha in the anterior stroma co-localized with alpha-smooth muscle actin (SMA) marker for myofibroblasts. In vitro studies have suggested that PDGF is important in the development and viability of myofibroblasts after corneal injury. Expression of PDGFR-alpha in myofibroblasts supports these findings.

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Year:  2009        PMID： 19344713      PMCID： PMC2720438          DOI： 10.1016/j.exer.2009.03.017

Source DB:  PubMed          Journal:  Exp Eye Res        ISSN： 0014-4835            Impact factor:   3.467


  14 in total

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Review 2.  Structure and function of the platelet-derived growth factor family and their receptors.

Authors:  K C Hart; B D Galvin; D J Donoghue
Journal:  Genet Eng (N Y)       Date:  1995

3.  Expression of alpha-smooth muscle (alpha-SM) actin during corneal stromal wound healing.

Authors:  J V Jester; W M Petroll; P A Barry; H D Cavanagh
Journal:  Invest Ophthalmol Vis Sci       Date:  1995-04       Impact factor: 4.799

4.  Transforming growth factor(beta)-mediated corneal myofibroblast differentiation requires actin and fibronectin assembly.

Authors:  J V Jester; J Huang; P A Barry-Lane; W W Kao; W M Petroll; H D Cavanagh
Journal:  Invest Ophthalmol Vis Sci       Date:  1999-08       Impact factor: 4.799

5.  Apoptosis, necrosis, proliferation, and myofibroblast generation in the stroma following LASIK and PRK.

Authors:  Rahul R Mohan; Audrey E K Hutcheon; Rosan Choi; JongWook Hong; JongSoo Lee; Rajiv R Mohan; Renato Ambrósio; James D Zieske; Steven E Wilson
Journal:  Exp Eye Res       Date:  2003-01       Impact factor: 3.467

6.  Corneal stroma PDGF blockade and myofibroblast development.

Authors:  Harmeet Kaur; Shyam S Chaurasia; Fabricio W de Medeiros; Vandana Agrawal; Marcella Q Salomao; Nirbhai Singh; Balamurali K Ambati; Steven E Wilson
Journal:  Exp Eye Res       Date:  2008-12-24       Impact factor: 3.467

7.  Epidermal growth factor, transforming growth factor alpha, transforming growth factor beta, acidic fibroblast growth factor, basic fibroblast growth factor, and interleukin-1 proteins in the cornea.

Authors:  S E Wilson; G S Schultz; N Chegini; J Weng; Y G He
Journal:  Exp Eye Res       Date:  1994-07       Impact factor: 3.467

8.  Myofibroblasts differentiate from fibroblasts when plated at low density.

Authors:  S K Masur; H S Dewal; T T Dinh; I Erenburg; S Petridou
Journal:  Proc Natl Acad Sci U S A       Date:  1996-04-30       Impact factor: 11.205

9.  Myofibroblast differentiation is induced in keratinocyte-fibroblast co-cultures and is antagonistically regulated by endogenous transforming growth factor-beta and interleukin-1.

Authors:  Pierre Shephard; Gail Martin; Sigrun Smola-Hess; Georg Brunner; Thomas Krieg; Hans Smola
Journal:  Am J Pathol       Date:  2004-06       Impact factor: 4.307

10.  Regional variation in distribution of EGF receptor in developing and adult corneal epithelium.

Authors:  J D Zieske; M Wasson
Journal:  J Cell Sci       Date:  1993-09       Impact factor: 5.285
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  7 in total

1.  Characterization of Inhibitor of differentiation (Id) proteins in human cornea.

Authors:  Rajiv R Mohan; Brandie R Morgan; Govindaraj Anumanthan; Ajay Sharma; Shyam S Chaurasia; Frank G Rieger
Journal:  Exp Eye Res       Date:  2015-12-19       Impact factor: 3.467

Review 2.  Corneal Regeneration After Photorefractive Keratectomy: A Review.

Authors:  Javier Tomás-Juan; Ane Murueta-Goyena Larrañaga; Ludger Hanneken
Journal:  J Optom       Date:  2014-10-23

Review 3.  Corneal myofibroblast biology and pathobiology: generation, persistence, and transparency.

Authors:  Steven E Wilson
Journal:  Exp Eye Res       Date:  2012-04-20       Impact factor: 3.467

4.  Electrophilic PPARγ ligands inhibit corneal fibroblast to myofibroblast differentiation in vitro: a potentially novel therapy for corneal scarring.

Authors:  A E Kuriyan; G M Lehmann; A A Kulkarni; C F Woeller; S E Feldon; H B Hindman; P J Sime; K R Huxlin; R P Phipps
Journal:  Exp Eye Res       Date:  2011-12-08       Impact factor: 3.467

5.  Induction of corneal myofibroblasts by lens-derived transforming growth factor beta1 (TGFbeta1): a transgenic mouse model.

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6.  A method to generate enhanced GFP+ chimeric mice to study the role of bone marrow-derived cells in the eye.

Authors:  Vivek Singh; Ritika Jaini; André A M Torricelli; Vincent K Tuohy; Steven E Wilson
Journal:  Exp Eye Res       Date:  2013-10-17       Impact factor: 3.467

7.  Genome-wide meta-analysis of five Asian cohorts identifies PDGFRA as a susceptibility locus for corneal astigmatism.

Authors:  Qiao Fan; Xin Zhou; Chiea-Chuen Khor; Ching-Yu Cheng; Liang-Kee Goh; Xueling Sim; Wan-Ting Tay; Yi-Ju Li; Rick Twee-Hee Ong; Chen Suo; Belinda Cornes; Mohammad Kamran Ikram; Kee-Seng Chia; Mark Seielstad; Jianjun Liu; Eranga Vithana; Terri L Young; E-Shyong Tai; Tien-Yin Wong; Tin Aung; Yik-Ying Teo; Seang-Mei Saw
Journal:  PLoS Genet       Date:  2011-12-01       Impact factor: 5.917
  7 in total

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