| Literature DB >> 19344403 |
Luca Castagna1, Stefania Bramanti, Monica Balzarotti, Barbara Sarina, Elisabetta Todisco, Antonella Anastasia, Massimo Magagnoli, Rita Mazza, Andrea Nozza, Laura Giordano, Marcello Rodari, Eva Rinifilo, Arturo Chiti, Armando Santoro.
Abstract
This retrospective study evaluated whether early 2-[fluorine-18]fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) after two cycles of salvage chemotherapy (PET2) could predict survival after high-dose chemotherapy (HDC). Twenty-four Hodgkin lymphoma (HL) patients were included. PET2 was negative in 58% and positive in 42% of patients. Ninety per cent of patients (9/10) with positive PET2 relapsed after HDC while all but one patient with negative PET2 maintained a complete remission. The 2-year progression-free survival was 93% vs. 10% for patients with negative and positive PET2, respectively (P < 0.001). This study shows that interim PET can predict the outcome after high-dose chemotherapy in HL patients.Entities:
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Year: 2009 PMID： 19344403 DOI： 10.1111/j.1365-2141.2009.07645.x
Source DB: PubMed Journal: Br J Haematol ISSN： 0007-1048 Impact factor: 6.998