Literature DB >> 19344076

Pediatric Atorvastatin in Diabetes Trial (PADIT): a pilot study to determine the effect of atorvastatin on arterial stiffness and endothelial function in children with type 1 diabetes mellitus.

Michael J Haller1, Jennifer M Stein, Jonathan J Shuster, Douglas Theriaque, Margaret M Samyn, Carl Pepine, Janet H Silverstein.   

Abstract

Fifty-one children with type 1 diabetes mellitus (DM1) participated in a double blinded, randomized, cross-over pilot study to determine whether 12 weeks of daily atorvastatin (20 mg daily) would reduce arterial stiffness and improve endothelial function. Secondary analysis demonstrated potential reduction of arterial stiffness following atorvastatin therapy (p = 0.06). Additional long-term prospective studies with larger numbers of patients are needed.

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Year:  2009        PMID： 19344076      PMCID： PMC3621084          DOI： 10.1515/jpem.2009.22.1.65

Source DB:  PubMed          Journal:  J Pediatr Endocrinol Metab        ISSN： 0334-018X            Impact factor:   1.634


  6 in total

1.  Standards of medical care in diabetes--2007.

Authors: 
Journal:  Diabetes Care       Date:  2007-01       Impact factor: 19.112

Review 2.  Type 1 diabetes and coronary artery disease.

Authors:  Trevor J Orchard; Tina Costacou; Adam Kretowski; Richard W Nesto
Journal:  Diabetes Care       Date:  2006-11       Impact factor: 19.112

3.  Statins and children: whom do we treat and when?

Authors:  Evan A Stein
Journal:  Circulation       Date:  2007-08-07       Impact factor: 29.690

4.  Drug therapy of high-risk lipid abnormalities in children and adolescents: a scientific statement from the American Heart Association Atherosclerosis, Hypertension, and Obesity in Youth Committee, Council of Cardiovascular Disease in the Young, with the Council on Cardiovascular Nursing.

Authors:  Brian W McCrindle; Elaine M Urbina; Barbara A Dennison; Marc S Jacobson; Julia Steinberger; Albert P Rocchini; Laura L Hayman; Stephen R Daniels
Journal:  Circulation       Date:  2007-03-21       Impact factor: 29.690

5.  Radial artery tonometry demonstrates arterial stiffness in children with type 1 diabetes.

Authors:  Michael J Haller; Margaret Samyn; Wilmer W Nichols; Todd Brusko; Clive Wasserfall; R Fletcher Schwartz; Mark Atkinson; Jonathan J Shuster; Gary L Pierce; Janet H Silverstein
Journal:  Diabetes Care       Date:  2004-12       Impact factor: 19.112

6.  Peripheral artery tonometry demonstrates altered endothelial function in children with type 1 diabetes.

Authors:  Michael J Haller; Jennifer Stein; Jon Shuster; Douglas Theriaque; Janet Silverstein; Desmond A Schatz; Michael G Earing; Amir Lerman; Farid H Mahmud
Journal:  Pediatr Diabetes       Date:  2007-08       Impact factor: 4.866
  6 in total
  11 in total

Review 1.  Cardiovascular disease risk in young people with type 1 diabetes.

Authors:  Janet K Snell-Bergeon; Kristen Nadeau
Journal:  J Cardiovasc Transl Res       Date:  2012-04-12       Impact factor: 4.132

2.  AdDIT Editorial comment-challenges in medication treatment of renal and cardiovascular diseases and risk factors in adolescents with type 1 diabetes.

Authors:  Fariba Ahmadizar; Anke H Maitland-van der Zee
Journal:  Ann Transl Med       Date:  2018-05

3.  Excess mortality and cardiovascular disease in young adults with type 1 diabetes in relation to age at onset: a nationwide, register-based cohort study.

Authors:  Araz Rawshani; Naveed Sattar; Stefan Franzén; Aidin Rawshani; Andrew T Hattersley; Ann-Marie Svensson; Björn Eliasson; Soffia Gudbjörnsdottir
Journal:  Lancet       Date:  2018-08-09       Impact factor: 79.321

4.  Endothelial abnormalities in adolescents with type 1 diabetes: a biomarker for vascular sequelae?

Authors:  Linda A DiMeglio; Aneesh Tosh; Chandan Saha; Myka Estes; Julie Mund; Laura E Mead; Izlin Lien; David A Ingram; Laura S Haneline
Journal:  J Pediatr       Date:  2010-06-12       Impact factor: 4.406

Review 5.  Risks and benefits of statin use in young people with type 1 diabetes.

Authors:  Petter Bjornstad; R Paul Wadwa
Journal:  Curr Diab Rep       Date:  2014-07       Impact factor: 4.810

Review 6.  Mitigating micro-and macro-vascular complications of diabetes beginning in adolescence.

Authors:  Daniel J Moore; Justin M Gregory; Yaa A Kumah-Crystal; Jill H Simmons
Journal:  Vasc Health Risk Manag       Date:  2009-11-23

Review 7.  Type 1 diabetes mellitus and cardiovascular disease: a scientific statement from the American Heart Association and American Diabetes Association.

Authors:  Sarah D de Ferranti; Ian H de Boer; Vivian Fonseca; Caroline S Fox; Sherita Hill Golden; Carl J Lavie; Sheela N Magge; Nikolaus Marx; Darren K McGuire; Trevor J Orchard; Bernard Zinman; Robert H Eckel
Journal:  Diabetes Care       Date:  2014-08-11       Impact factor: 19.112

Review 8.  Hypertriglyceridemia in Diabetes Mellitus: Implications for Pediatric Care.

Authors:  Jacob C Hartz; Sarah de Ferranti; Samuel Gidding
Journal:  J Endocr Soc       Date:  2018-05-01

Review 9.  Modifiable Risk Factors for Cardiovascular Disease in Children with Type 1 Diabetes: Can Early Intervention Prevent Future Cardiovascular Events?

Authors:  Evgenia Gourgari; Dana Dabelea; Kristina Rother
Journal:  Curr Diab Rep       Date:  2017-11-03       Impact factor: 4.810

10.  Lessons learned from a lipid lowering trial in adolescents with type 1 diabetes.

Authors:  Franziska K Bishop; R Paul Wadwa; Sam Ellis; Marian Rewers; David M Maahs
Journal:  Int J Pediatr Endocrinol       Date:  2012-07-30
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