| Literature DB >> 19342331 |
Chun-Hao Chen1, Rong-Zhang Hwang, Long-Sun Huang, Shi-Ming Lin, Hsiao-Chin Chen, Yu-Che Yang, Yu-Tso Lin, Shih-An Yu, Yo-Sheng Lin, Yiao-Hong Wang, Nai-Kuan Chou, Shey-Shi Lu.
Abstract
A quick wireless label-free detection of disease-related C-reactive proteins (CRPs) using a 200-microm-long microelectromechanical systems (MEMS) microcantilever housed in a 7 x 7 mm(2) reaction chamber with a safe reusable feature is reported. The assay time ranges from about 30 min to 3 h, depending on accuracy. The deflection of the microcantilever due to specific CRP-antiCRP binding is detected using a position-sensitive detector. The converted bio-signal is transmitted by a custom designed wireless amplitude-shift-keying (ASK) transceiver IC fabricated in a 0.18 microm CMOS process. CRP concentrations from 1 microg/mL to 500 microg/mL can be detected. A 0.2-Hz 1-V ac signal instead of traditional bases/acids is applied to the bio-MEMS sensor to unbind the CRP from the microcantilever for reusability.Mesh：
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Year: 2009 PMID： 19342331 DOI： 10.1109/TBME.2008.2003262
Source DB: PubMed Journal: IEEE Trans Biomed Eng ISSN： 0018-9294 Impact factor: 4.538