PURPOSE: We examined the associations between lifestyle factors and the risk of amyotrophic lateral sclerosis (ALS) using a case-control study in Aichi Prefecture, Japan. METHODS: The study comprised 183 ALS patients diagnosed by the El Escorial World Federation of Neurology criteria as well as 366 gender- and age-matched controls randomly selected from the general population with the use of the basic register of residents. Detailed information on lifestyle factors was obtained through a mailed self-administered questionnaire. The strength of association between ALS and a potential risk factor was assessed by calculating odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: Vigorous physical activity, self reported stress, a type A behavior pattern, and less frequent intakes of green-yellow vegetables were significantly associated with increased risk of ALS, whereas smoking and drinking habits were not. The greatest effect on risk for ALS was posed by the combination of a type A behavior pattern and less frequent intakes of green-yellow vegetables (adjusted OR, 11.2; 95% CI, 3.8 to 33.0). CONCLUSION: These data suggested that imbalances between excessive productions of oxidants as patient-specific factors and a diminished or missing antioxidant defense system in motor neurons may increase the risk of ALS.
PURPOSE: We examined the associations between lifestyle factors and the risk of amyotrophic lateral sclerosis (ALS) using a case-control study in Aichi Prefecture, Japan. METHODS: The study comprised 183 ALSpatients diagnosed by the El Escorial World Federation of Neurology criteria as well as 366 gender- and age-matched controls randomly selected from the general population with the use of the basic register of residents. Detailed information on lifestyle factors was obtained through a mailed self-administered questionnaire. The strength of association between ALS and a potential risk factor was assessed by calculating odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: Vigorous physical activity, self reported stress, a type A behavior pattern, and less frequent intakes of green-yellow vegetables were significantly associated with increased risk of ALS, whereas smoking and drinking habits were not. The greatest effect on risk for ALS was posed by the combination of a type A behavior pattern and less frequent intakes of green-yellow vegetables (adjusted OR, 11.2; 95% CI, 3.8 to 33.0). CONCLUSION: These data suggested that imbalances between excessive productions of oxidants as patient-specific factors and a diminished or missing antioxidant defense system in motor neurons may increase the risk of ALS.
Authors: Bello Hamidou; Philippe Couratier; Cyril Besançon; Marie Nicol; Pierre Marie Preux; Benoit Marin Journal: Eur J Epidemiol Date: 2014-07-02 Impact factor: 8.082
Authors: Restuadi Restuadi; Fleur C Garton; Beben Benyamin; Tian Lin; Kelly L Williams; Anna Vinkhuyzen; Wouter van Rheenen; Zhihong Zhu; Nigel G Laing; Karen A Mather; Perminder S Sachdev; Shyuan T Ngo; Frederik J Steyn; Leanne Wallace; Anjali K Henders; Peter M Visscher; Merrilee Needham; Susan Mathers; Garth Nicholson; Dominic B Rowe; Robert D Henderson; Pamela A McCombe; Roger Pamphlett; Ian P Blair; Naomi R Wray; Allan F McRae Journal: Eur J Hum Genet Date: 2021-04-27 Impact factor: 5.351
Authors: Valentina Gallo; Nicola Vanacore; H Bas Bueno-de-Mesquita; Roel Vermeulen; Carol Brayne; Neil Pearce; Petra A Wark; Heather A Ward; Pietro Ferrari; Mazda Jenab; Peter M Andersen; Patrik Wennberg; Nicholas Wareham; Verena Katzke; Rudolf Kaaks; Elisabete Weiderpass; Petra H Peeters; Amalia Mattiello; Valeria Pala; Aurelio Barricante; Maria-Dolores Chirlaque; Noémie Travier; Ruth C Travis; Maria-Jose Sanchez; Hélène Pessah-Rasmussen; Jesper Petersson; Anne Tjønneland; Rosario Tumino; Jose Ramon Quiros; Antonia Trichopoulou; Andreas Kyrozis; Despoina Oikonomidou; Giovanna Masala; Carlotta Sacerdote; Larraitz Arriola; Heiner Boeing; Matthaeus Vigl; Francoise Claver-Chapelon; Lefkos Middleton; Elio Riboli; Paolo Vineis Journal: Eur J Epidemiol Date: 2016-03-11 Impact factor: 8.082