| Literature DB >> 19342181 |
Haizhi Quan1, Fei Zhu, Xinyan Han, Zirong Xu, Yilong Zhao, Zhiguo Miao.
Abstract
Metastatic disease is the primary cause of death for most cancer patients. Angiogenesis is the formation of a new capillary network from pre-existing vessels and required for tumor vasculature. Heparanase, a beta-endoglucuronidase, assistants tumor invasion, metastasis and angiogenesis. Chitooligosaccharides (COS) is obtained by hydrolysis of chitosan. COS has been proved to be anti-angiogenesis activity. The mechanism of COS inhibits angiogenesis is not very clear, COS is hypothesized by author to be an inhibitor of heparanase.Entities:
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Year: 2009 PMID： 19342181 DOI： 10.1016/j.mehy.2009.02.018
Source DB: PubMed Journal: Med Hypotheses ISSN： 0306-9877 Impact factor: 1.538