OBJECTIVE: To study ovarian follicular dynamics during chemotherapy to understand the mechanisms behind chemotherapy-induced ovarian follicular depletion and to evaluate whether pretreatment levels of ovarian reserve markers were predictive of the posttreatment levels. DESIGN: Prospective clinical study. SETTING: University hospital fertility center. PATIENT(S): Seventeen women (median age 30 years; range 19-35 years) undergoing chemotherapy. INTERVENTION(S): Patients were seen before, frequently during, and after chemotherapy, until 1 year after the end of treatment. Antral follicle count and levels of FSH, LH, E(2), anti-Müllerian hormone (AMH), and inhibin A and B were monitored at each visit. MAIN OUTCOME MEASURE(S): The dynamics of the ovarian reserve markers during chemotherapy and factors predictive of posttreatment ovarian function. RESULT(S): Anti-Müllerian hormone level (mean +/- 2 SEM) dropped from 2.7 +/- 1.0 to 1.1 +/- 0.6 and to 0.4 +/- 0.4 ng/mL immediately after one and two series of chemotherapy, respectively. Inhibin B and antral follicle count decreased after three series whereas FSH reached menopausal levels after four series. High pretreatment AMH levels predicted higher posttreatment AMH levels. CONCLUSION(S): Anti-Müllerian hormone and inhibin B levels immediately declined in response to chemotherapy, and the follicular target of chemotherapy appeared to be growing follicles. High pretreatment AMH levels were predictive of a higher posttreatment AMH level. Copyright (c) 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
OBJECTIVE: To study ovarian follicular dynamics during chemotherapy to understand the mechanisms behind chemotherapy-induced ovarian follicular depletion and to evaluate whether pretreatment levels of ovarian reserve markers were predictive of the posttreatment levels. DESIGN: Prospective clinical study. SETTING: University hospital fertility center. PATIENT(S): Seventeen women (median age 30 years; range 19-35 years) undergoing chemotherapy. INTERVENTION(S): Patients were seen before, frequently during, and after chemotherapy, until 1 year after the end of treatment. Antral follicle count and levels of FSH, LH, E(2), anti-Müllerian hormone (AMH), and inhibin A and B were monitored at each visit. MAIN OUTCOME MEASURE(S): The dynamics of the ovarian reserve markers during chemotherapy and factors predictive of posttreatment ovarian function. RESULT(S): Anti-Müllerian hormone level (mean +/- 2 SEM) dropped from 2.7 +/- 1.0 to 1.1 +/- 0.6 and to 0.4 +/- 0.4 ng/mL immediately after one and two series of chemotherapy, respectively. Inhibin B and antral follicle count decreased after three series whereas FSH reached menopausal levels after four series. High pretreatment AMH levels predicted higher posttreatment AMH levels. CONCLUSION(S): Anti-Müllerian hormone and inhibin B levels immediately declined in response to chemotherapy, and the follicular target of chemotherapy appeared to be growing follicles. High pretreatment AMH levels were predictive of a higher posttreatment AMH level. Copyright (c) 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Authors: Ashlesha Patel; Alicia Roston; Almae Uy; Erika Radeke; Arden Roston; Louis Keith; H A Zaren Journal: Support Care Cancer Date: 2014-08-15 Impact factor: 3.603
Authors: N Sinha; J M Letourneau; K Wald; P Xiong; Tal Imbar; B Li; E Harris; E Mok-Lin; M I Cedars; Mitchell P Rosen Journal: J Assist Reprod Genet Date: 2018-07-31 Impact factor: 3.412
Authors: Francesca E Duncan; Jennifer K Jozefik; Alison M Kim; Jennifer Hirshfeld-Cytron; Teresa K Woodruff Journal: US Obstet Gynecol Date: 2011-01-01
Authors: Shari B Goldfarb; Sabrina A Kamer; Bridget A Oppong; Anne Eaton; Sujata Patil; Manuela J Junqueira; Cristina Olcese; Joanne F Kelvin; Mary L Gemignani Journal: Ann Surg Oncol Date: 2016-01-20 Impact factor: 5.344