Literature DB >> 19341714

The Ski protein can inhibit ligand induced RARalpha and HDAC3 degradation in the retinoic acid signaling pathway.

Hong-Ling Zhao1, Nobuhide Ueki, Katherine Marcelain, Michael J Hayman.   

Abstract

Recent data has implicated the Ski protein as being a physiologically relevant negative regulator of signaling by retinoic acid (RA). The mechanism by which Ski represses RA signaling is unknown. Co-immunoprecipitation and immunofluorescence assay showed that Ski and RARalpha are in the same complex in both the absence and presence of RA, which makes Ski different from other corepressors. We determined that Ski can stabilize RARalpha and HDAC3. These results suggest that Ski represses RA signaling by stabilizing corepressor complex.

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Year:  2009        PMID： 19341714      PMCID： PMC2695671          DOI： 10.1016/j.bbrc.2009.03.141

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  28 in total

1.  Structure of the RXR-RAR DNA-binding complex on the retinoic acid response element DR1.

Authors:  F Rastinejad; T Wagner; Q Zhao; S Khorasanizadeh
Journal:  EMBO J       Date:  2000-03-01       Impact factor: 11.598

2.  Dimerization with retinoid X receptors and phosphorylation modulate the retinoic acid-induced degradation of retinoic acid receptors alpha and gamma through the ubiquitin-proteasome pathway.

Authors:  E Kopf; J L Plassat; V Vivat; H de Thé; P Chambon; C Rochette-Egly
Journal:  J Biol Chem       Date:  2000-10-27       Impact factor: 5.157

Review 3.  Nuclear hormone receptors and gene expression.

Authors:  A Aranda; A Pascual
Journal:  Physiol Rev       Date:  2001-07       Impact factor: 37.312

4.  Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26S proteasome.

Authors:  C A Lange; T Shen; K B Horwitz
Journal:  Proc Natl Acad Sci U S A       Date:  2000-02-01       Impact factor: 11.205

5.  Ski can negatively regulates macrophage differentiation through its interaction with PU.1.

Authors:  N Ueki; L Zhang; M J Hayman; M J Haymann
Journal:  Oncogene       Date:  2007-07-09       Impact factor: 9.867

6.  Hormone binding induces rapid proteasome-mediated degradation of thyroid hormone receptors.

Authors:  A Dace; L Zhao; K S Park; T Furuno; N Takamura; M Nakanishi; B L West; J A Hanover; S Cheng
Journal:  Proc Natl Acad Sci U S A       Date:  2000-08-01       Impact factor: 11.205

7.  Loss of the SKI proto-oncogene in individuals affected with 1p36 deletion syndrome is predicted by strain-dependent defects in Ski-/- mice.

Authors:  Clemencia Colmenares; Heidi A Heilstedt; Lisa G Shaffer; Stuart Schwartz; Michael Berk; Jeffrey C Murray; Ed Stavnezer
Journal:  Nat Genet       Date:  2001-12-03       Impact factor: 38.330

8.  The 26S proteasome is required for estrogen receptor-alpha and coactivator turnover and for efficient estrogen receptor-alpha transactivation.

Authors:  D M Lonard; Z Nawaz; C L Smith; B W O'Malley
Journal:  Mol Cell       Date:  2000-06       Impact factor: 17.970

9.  Ocular abnormalities in mice lacking the Ski proto-oncogene.

Authors:  Peter McGannon; Yasumasa Miyazaki; Pankaj C Gupta; Elias I Traboulsi; Clemencia Colmenares
Journal:  Invest Ophthalmol Vis Sci       Date:  2006-10       Impact factor: 4.799

10.  Ski co-repressor complexes maintain the basal repressed state of the TGF-beta target gene, SMAD7, via HDAC3 and PRMT5.

Authors:  Takanori Tabata; Kenji Kokura; Peter Ten Dijke; Shunsuke Ishii
Journal:  Genes Cells       Date:  2008-11-21       Impact factor: 1.891
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  8 in total

1.  Chromosomal instability in mouse embryonic fibroblasts null for the transcriptional co-repressor Ski.

Authors:  Katherine Marcelain; Ricardo Armisen; Adam Aguirre; Nobuhide Ueki; Jessica Toro; Clemencia Colmenares; Michael J Hayman
Journal:  J Cell Physiol       Date:  2012-01       Impact factor: 6.384

2.  Identification of Ski as a target for Aurora A kinase.

Authors:  Jocelyn Mosquera; Ricardo Armisen; Hongling Zhao; Diego A Rojas; Edio Maldonado; Julio C Tapia; Alicia Colombo; Michael J Hayman; Katherine Marcelain
Journal:  Biochem Biophys Res Commun       Date:  2011-05-12       Impact factor: 3.575

3.  SKI promotes Smad3 linker phosphorylations associated with the tumor-promoting trait of TGFbeta.

Authors:  Qiushi Lin; Dahu Chen; Nikolai A Timchenko; Estela E Medrano
Journal:  Cell Cycle       Date:  2010-05-21       Impact factor: 4.534

4.  The Ski protein negatively regulates Siah2-mediated HDAC3 degradation.

Authors:  Hong-Ling Zhao; Nobuhide Ueki; Michael J Hayman
Journal:  Biochem Biophys Res Commun       Date:  2010-08-04       Impact factor: 3.575

5.  Nuclear GRP75 binds retinoic acid receptors to promote neuronal differentiation of neuroblastoma.

Authors:  Yu-Yin Shih; Hsinyu Lee; Akira Nakagawara; Hseuh-Fen Juan; Yung-Ming Jeng; Yeou-Guang Tsay; Dong-Tsamn Lin; Fon-Jou Hsieh; Chien-Yuan Pan; Wen-Ming Hsu; Yung-Feng Liao
Journal:  PLoS One       Date:  2011-10-14       Impact factor: 3.240

6.  MYB induces the expression of the oncogenic corepressor SKI in acute myeloid leukemia.

Authors:  Miriam Frech; Sabine Teichler; Christine Feld; Caroline Bouchard; Hannah Berberich; Katharina Sorg; Marco Mernberger; Lars Bullinger; Uta-Maria Bauer; Andreas Neubauer
Journal:  Oncotarget       Date:  2018-04-27

7.  Transcriptional cofactors Ski and SnoN are major regulators of the TGF-β/Smad signaling pathway in health and disease.

Authors:  Angeles C Tecalco-Cruz; Diana G Ríos-López; Genaro Vázquez-Victorio; Reyna E Rosales-Alvarez; Marina Macías-Silva
Journal:  Signal Transduct Target Ther       Date:  2018-06-08

8.  Combined cistrome and transcriptome analysis of SKI in AML cells identifies SKI as a co-repressor for RUNX1.

Authors:  Christine Feld; Peeyush Sahu; Miriam Frech; Florian Finkernagel; Andrea Nist; Thorsten Stiewe; Uta-Maria Bauer; Andreas Neubauer
Journal:  Nucleic Acids Res       Date:  2018-04-20       Impact factor: 16.971
  8 in total

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