Literature DB >> 193416

Gonadotrophin levels in male rats following impairment of Leydig cell function by ethylene dimethanesulphonate.

C M Jackson, I D Morris.   

Abstract

The effects of the antispermatogenic compound, ethylene dimethanesulphonate on anterior pituitary and serum FSH, LH and prolactin levels in male rats were investigated. A rapid and sustained rise in serum LH, reaching castrate levels, indictated a normal pituitary response to androgen deprivation. Whilst no change in prolactin was observed, serum FSH showed a biphasic increase which is discussed in relation to the spermatogenic process.

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Year:  1977        PMID： 193416     DOI： 10.1111/j.1439-0272.1977.tb01255.x

Source DB:  PubMed          Journal:  Andrologia        ISSN： 0303-4569            Impact factor:   2.775


  5 in total

Review 1.  Recent advances in the human physiology of inhibin secretion.

Authors:  D M de Kretser; D M Robertson; G P Risbridger
Journal:  J Endocrinol Invest       Date:  1990 Jul-Aug       Impact factor: 4.256

2.  Regeneration of Leydig cells in unilaterally cryptorchid rats: evidence for stimulation by local testicular factors.

Authors:  J B Kerr; K Donachie
Journal:  Cell Tissue Res       Date:  1986       Impact factor: 5.249

3.  Selective destruction and regeneration of rat Leydig cells in vivo. A new method for the study of seminiferous tubular-interstitial tissue interaction.

Authors:  J B Kerr; K Donachie; F F Rommerts
Journal:  Cell Tissue Res       Date:  1985       Impact factor: 5.249

4.  Origin of regenerating Leydig cells in the testis of the adult rat. An ultrastructural, morphometric and hormonal assay study.

Authors:  J B Kerr; J M Bartlett; K Donachie; R M Sharpe
Journal:  Cell Tissue Res       Date:  1987-08       Impact factor: 5.249

5.  Acute response of testicular interstitial tissue in rats to the cytotoxic drug ethane dimethanesulphonate. An ultrastructural and hormonal assay study.

Authors:  J B Kerr; J M Bartlett; K Donachie
Journal:  Cell Tissue Res       Date:  1986       Impact factor: 5.249
  5 in total

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