Literature DB >> 19340654

Aberrant DNA methylation in thymic epithelial tumors.

Chen Chen1, Bangliang Yin, Qiyou Wei, Daiqiang Li, Jianguo Hu, Fenglei Yu, Qianjin Lu.   

Abstract

Aberrant DNA methylation plays a critical role in the development and progression of many types of cancer. To investigate whether DNA methylation is abnormal in thymic epithelial tumors (TETs), we analyzed global methylation levels and the methylation status of 9 tumor suppressor gene (TSG) promoters in 65 TET samples. We found evidence of TSG promoter hypermethylation and decreased TSG expression in severe TETs. Furthermore, relative to early-stage TETs, global DNA methylation levels were reduced and DNA methyltransferase expression was increased in advanced-stage TETs. Our results suggest that aberrant DNA methylation is associated with TET development.

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Year:  2009        PMID： 19340654     DOI： 10.1080/07357900802620869

Source DB:  PubMed          Journal:  Cancer Invest        ISSN： 0735-7907            Impact factor:   2.176


  9 in total

Review 1.  The 2015 World Health Organization Classification of Tumors of the Thymus: Continuity and Changes.

Authors:  Alexander Marx; John K C Chan; Jean-Michel Coindre; Frank Detterbeck; Nicolas Girard; Nancy L Harris; Elaine S Jaffe; Michael O Kurrer; Edith M Marom; Andre L Moreira; Kiyoshi Mukai; Attilio Orazi; Philipp Ströbel
Journal:  J Thorac Oncol       Date:  2015-10       Impact factor: 15.609

2.  DNA methylation dysregulations in valvular atrial fibrillation.

Authors:  Kangjun Shen; Tao Tu; Zhaoshun Yuan; Jiangfeng Yi; Yangzhao Zhou; Xiaobo Liao; Qiming Liu; Xinmin Zhou
Journal:  Clin Cardiol       Date:  2017-08-28       Impact factor: 2.882

3.  Genome-wide profiling of DNA methylation and gene expression in esophageal squamous cell carcinoma.

Authors:  Chen Chen; Hao Peng; Xiaojie Huang; Ming Zhao; Zhi Li; Ni Yin; Xiang Wang; Fenglei Yu; Bangliang Yin; Yunchang Yuan; Qianjin Lu
Journal:  Oncotarget       Date:  2016-01-26

4.  Gene-Specific Methylation Analysis in Thymomas of Patients with Myasthenia Gravis.

Authors:  Angela Lopomo; Roberta Ricciardi; Michelangelo Maestri; Anna De Rosa; Franca Melfi; Marco Lucchi; Alfredo Mussi; Fabio Coppedè; Lucia Migliore
Journal:  Int J Mol Sci       Date:  2016-12-16       Impact factor: 5.923

5.  DNA methylation dysregulations in rheumatic heart valve disease.

Authors:  Kangjun Shen; Hui Liu; Ran Jing; Jiangfeng Yi; Xinmin Zhou
Journal:  BMC Cardiovasc Disord       Date:  2017-06-17       Impact factor: 2.298

Review 6.  Thymic Epithelial Neoplasms: Focusing on the Epigenetic Alterations.

Authors:  Iason Psilopatis; Alexandros Pergaris; Kleio Vrettou; Stamatios Theocharis; Constantinos Troungos
Journal:  Int J Mol Sci       Date:  2022-04-06       Impact factor: 5.923

7.  Association of the DNMT3B -579G>T polymorphism with risk of thymomas in patients with myasthenia gravis.

Authors:  Fabio Coppedè; Roberta Ricciardi; Maria Denaro; Anna De Rosa; Carlo Provenzano; Emanuela Bartoccioni; Angelo Baggiani; Marco Lucchi; Alfredo Mussi; Lucia Migliore
Journal:  PLoS One       Date:  2013-11-19       Impact factor: 3.240

8.  Integrated analysis of DNA methylation profiling and gene expression profiling identifies novel markers in lung cancer in Xuanwei, China.

Authors:  Juan Wang; Yong Duan; Qing-He Meng; Rong Gong; Chong Guo; Ying Zhao; Yanliang Zhang
Journal:  PLoS One       Date:  2018-10-04       Impact factor: 3.240

9.  Investigation of MLH1, MGMT, CDKN2A, and RASSF1A Gene Methylation in Thymomas From Patients With Myasthenia Gravis.

Authors:  Fabio Coppedè; Roberta Ricciardi; Angela Lopomo; Andrea Stoccoro; Anna De Rosa; Melania Guida; Loredana Petrucci; Michelangelo Maestri; Marco Lucchi; Lucia Migliore
Journal:  Front Mol Neurosci       Date:  2020-10-23       Impact factor: 5.639
  9 in total

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