Literature DB >> 19339577

Higher opioid doses predict poorer functional outcome in patients with chronic disabling occupational musculoskeletal disorders.

Cindy L Kidner1, Tom G Mayer, Robert J Gatchel.   

Abstract

BACKGROUND: Opioids are frequently used for the postoperative treatment of chronic disabling occupational musculoskeletal disorders. In many such cases, long-term opioid use persists because of patient requests for ongoing pain relief. Little is known about the relationship between chronic opioid use and functional recovery in these patients.
METHODS: A total of 1226 patients with a chronic disabling occupational musculoskeletal disorder were consecutively admitted into an interdisciplinary functional restoration program. They were divided into two groups: 630 patients who reported no opioid use at the time of admission (No group) and 596 patients who reported some opioid use at the time of admission (Yes group). The 516 patients for whom daily opioid doses could be determined were further divided into four subgroups: Low (<30 mg, n=267), Medium (31 to 60 mg, n=112), High (61 to 120 mg, n=78), and Very High (>120 mg, n=59). During the initial weeks of treatment, patients consented to be weaned from all opioid medications. In addition, the patients were assessed before and after rehabilitation with regard to self-reported measures of pain, function, and depression and were analyzed for change. One year after the termination of treatment, socioeconomic outcomes were assessed to measure work and financial status, healthcare utilization, and recurrent injury-associated pain.
RESULTS: A higher post-injury opioid dose was associated with a greater risk of program noncompletion, which was anticipated because of the requirement that patients taper opioids. High opioid use was significantly related to important socioeconomic outcomes, such as lower rates of return to work and work retention as well as higher healthcare utilization (p<or=0.05 for all). Moreover, at one year after treatment, the group reporting the highest opioid use was 11.6 times as likely to be receiving Social Security Disability Income/Supplemental Security Income as compared with the group reporting no opioid use at the time of admission into the program.
CONCLUSIONS: Chronic opioid use beginning after a work-related injury is a predictor of less successful outcomes for patients whose final treatment intervention is an interdisciplinary functional restoration program. Higher dose levels are associated with progressively greater indemnity and medical costs for ongoing disability. Physicians involved in the treatment of chronic disabling occupational musculoskeletal disorders should be aware of problems associated with permitting long-term opioid use in patients with a disabling occupational disorder.

Entities:  

Mesh:

Substances:

Year:  2009        PMID: 19339577      PMCID: PMC2665041          DOI: 10.2106/JBJS.H.00286

Source DB:  PubMed          Journal:  J Bone Joint Surg Am        ISSN: 0021-9355            Impact factor:   5.284


  37 in total

1.  The pain disability questionnaire: relationship to one-year functional and psychosocial rehabilitation outcomes.

Authors:  Robert J Gatchel; Tom G Mayer; Brian R Theodore
Journal:  J Occup Rehabil       Date:  2006-03

2.  Evidence for a long-term influence on morphine tolerance after previous morphine exposure: role of neuronal glucocorticoid receptors.

Authors:  Grewo Lim; Shuxing Wang; Qing Zeng; Backil Sung; Jianren Mao
Journal:  Pain       Date:  2004-12-25       Impact factor: 6.961

Review 3.  Systematic review: opioid treatment for chronic back pain: prevalence, efficacy, and association with addiction.

Authors:  Bridget A Martell; Patrick G O'Connor; Robert D Kerns; William C Becker; Knashawn H Morales; Thomas R Kosten; David A Fiellin
Journal:  Ann Intern Med       Date:  2007-01-16       Impact factor: 25.391

4.  Opioid tolerance and hyperalgesia in chronic pain patients after one month of oral morphine therapy: a preliminary prospective study.

Authors:  Larry F Chu; David J Clark; Martin S Angst
Journal:  J Pain       Date:  2006-01       Impact factor: 5.820

Review 5.  What's wrong with Bonferroni adjustments.

Authors:  T V Perneger
Journal:  BMJ       Date:  1998-04-18

6.  Recurrent or new injury outcomes after return to work in chronic disabling spinal disorders. Tertiary prevention efficacy of functional restoration treatment.

Authors:  P Garcy; T Mayer; R J Gatchel
Journal:  Spine (Phila Pa 1976)       Date:  1996-04-15       Impact factor: 3.468

7.  Evaluation of low back pain and assessment of lumbar corsets with and without back supports.

Authors:  R Million; K H Nilsen; M I Jayson; R D Baker
Journal:  Ann Rheum Dis       Date:  1981-10       Impact factor: 19.103

8.  High pain ratings predict treatment failure in chronic occupational musculoskeletal disorders.

Authors:  Donald D McGeary; Tom G Mayer; Robert J Gatchel
Journal:  J Bone Joint Surg Am       Date:  2006-02       Impact factor: 5.284

Review 9.  Evidence-based scientific data documenting the treatment and cost-effectiveness of comprehensive pain programs for chronic nonmalignant pain.

Authors:  Robert J Gatchel; Akiko Okifuji
Journal:  J Pain       Date:  2006-11       Impact factor: 5.820

10.  Impact of functional restoration after anterior cervical fusion on chronic disability in work-related neck pain.

Authors:  Tom G Mayer; Christopher Anagnostis; Robert J Gatchel; Trent Evans
Journal:  Spine J       Date:  2002 Jul-Aug       Impact factor: 4.166

View more
  56 in total

Review 1.  Adverse events associated with medium- and long-term use of opioids for chronic non-cancer pain: an overview of Cochrane Reviews.

Authors:  Charl Els; Tanya D Jackson; Diane Kunyk; Vernon G Lappi; Barend Sonnenberg; Reidar Hagtvedt; Sangita Sharma; Fariba Kolahdooz; Sebastian Straube
Journal:  Cochrane Database Syst Rev       Date:  2017-10-30

2.  Excess Opioid Medication and Variation in Prescribing Patterns Following Common Orthopaedic Procedures.

Authors:  Matthew J Sabatino; Samuel T Kunkel; Dipak B Ramkumar; Benjamin J Keeney; David S Jevsevar
Journal:  J Bone Joint Surg Am       Date:  2018-02-07       Impact factor: 5.284

3.  Patterns of care and side effects for patients prescribed methadone for treatment of chronic pain.

Authors:  Tara A Macey; Melissa B Weimer; Elizabeth M Grimaldi; Steven K Dobscha; Benjamin J Morasco
Journal:  J Opioid Manag       Date:  2013 Sep-Oct

Review 4.  Mechanisms that drive bone pain across the lifespan.

Authors:  Patrick W Mantyh
Journal:  Br J Clin Pharmacol       Date:  2018-11-22       Impact factor: 4.335

Review 5.  Medical and psychological risks and consequences of long-term opioid therapy in women.

Authors:  Beth D Darnall; Brett R Stacey; Roger Chou
Journal:  Pain Med       Date:  2012-08-20       Impact factor: 3.750

6.  The clinical utility of the Multidimensional Pain Inventory (MPI) in characterizing chronic disabling occupational musculoskeletal disorders.

Authors:  YunHee Choi; Tom G Mayer; Mark Williams; Robert J Gatchel
Journal:  J Occup Rehabil       Date:  2013-06

7.  Opioid use prior to total hip arthroplasty leads to worse clinical outcomes.

Authors:  Robert Pivec; Kimona Issa; Qais Naziri; Bhaveen H Kapadia; Peter M Bonutti; Michael A Mont
Journal:  Int Orthop       Date:  2014-02-27       Impact factor: 3.075

8.  Unintentional prescription opioid-related overdose deaths: description of decedents by next of kin or best contact, Utah, 2008-2009.

Authors:  Erin M Johnson; William A Lanier; Ray M Merrill; Jacob Crook; Christina A Porucznik; Robert T Rolfs; Brian Sauer
Journal:  J Gen Intern Med       Date:  2012-10-16       Impact factor: 5.128

9.  Lumbar surgery in work-related chronic low back pain: can a continuum of care enhance outcomes?

Authors:  Tom G Mayer; Robert J Gatchel; Emily Brede; Brian R Theodore
Journal:  Spine J       Date:  2013-11-12       Impact factor: 4.166

10.  Does opioid pain medication use affect the outcome of patients with lumbar disc herniation?

Authors:  Kristen Radcliff; Mitchell Freedman; Alan Hilibrand; Roman Isaac; Jon D Lurie; Wenyan Zhao; Alex Vaccaro; Todd Albert; James N Weinstein
Journal:  Spine (Phila Pa 1976)       Date:  2013-06-15       Impact factor: 3.468

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.