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Literature DB >> 19339348

Splicing of the large intron present in the nonstructural gene of minute virus of mice is governed by TIA-1/TIAR binding downstream of the nonconsensus donor.

Abstract

The essential proteins NS1 and NS2 of minute virus of mice are encoded by mRNAs R1 and R2, respectively. R2 is derived from R1 by excision of a large intron and thus splicing governs the relative ratios of NS1 and NS2. Excision of the large intron utilizes a nonconsensus 5' donor site. We identified a U-rich and A-rich intronic sequence immediately downstream of the nonconsensus 5' donor site that functions as an intronic splicing enhancer (ISE) required for efficient large-intron excision. The ISE binds the cellular RNA-processing proteins TIA-1 and TIAR, which enhance usage of the nonconsensus donor.

Entities: Gene Species

Mesh：

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Year: 2009 PMID： 19339348 PMCID： PMC2687395 DOI： 10.1128/JVI.00213-09

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

29 in total

1. Interaction between parvovirus NS2 protein and nuclear export factor Crm1 is important for viral egress from the nucleus of murine cells.

Authors: Cathy L Miller; David J Pintel
Journal: J Virol Date: 2002-04 Impact factor: 5.103

2. TIA-1 and TIAR activate splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on their own pre-mRNAs.

Authors: C Le Guiner; F Lejeune; D Galiana; L Kister; R Breathnach; J Stévenin; F Del Gatto-Konczak
Journal: J Biol Chem Date: 2001-08-20 Impact factor: 5.157

3. The adeno-associated virus type 2 Rep protein regulates RNA processing via interaction with the transcription template.

Authors: Jianming Qiu; David J Pintel
Journal: Mol Cell Biol Date: 2002-06 Impact factor: 4.272

Review 4. Mechanisms of alternative pre-messenger RNA splicing.

Authors: Douglas L Black
Journal: Annu Rev Biochem Date: 2003-02-27 Impact factor: 23.643

5. The RNA-binding protein TIA-1 is a novel mammalian splicing regulator acting through intron sequences adjacent to a 5' splice site.

Authors: F Del Gatto-Konczak; C F Bourgeois; C Le Guiner; L Kister; M C Gesnel; J Stévenin; R Breathnach
Journal: Mol Cell Biol Date: 2000-09 Impact factor: 4.272

6. Predictive identification of exonic splicing enhancers in human genes.

Authors: William G Fairbrother; Ru-Fang Yeh; Phillip A Sharp; Christopher B Burge
Journal: Science Date: 2002-07-11 Impact factor: 47.728

7. The apoptosis-promoting factor TIA-1 is a regulator of alternative pre-mRNA splicing.

Authors: P Förch; O Puig; N Kedersha; C Martínez; S Granneman; B Séraphin; P Anderson; J Valcárcel
Journal: Mol Cell Date: 2000-11 Impact factor: 17.970

8. Human GC-AG alternative intron isoforms with weak donor sites show enhanced consensus at acceptor exon positions.

Authors: T A Thanaraj; F Clark
Journal: Nucleic Acids Res Date: 2001-06-15 Impact factor: 16.971

9. An intronic polypyrimidine-rich element downstream of the donor site modulates cystic fibrosis transmembrane conductance regulator exon 9 alternative splicing.

Authors: Elisabetta Zuccato; Emanuele Buratti; Cristiana Stuani; Francisco E Baralle; Franco Pagani
Journal: J Biol Chem Date: 2004-02-13 Impact factor: 5.157

Splicing of the large intron present in the nonstructural gene of minute virus of mice is governed by TIA-1/TIAR binding downstream of the nonconsensus donor.

1. Interaction between parvovirus NS2 protein and nuclear export factor Crm1 is important for viral egress from the nucleus of murine cells.

2. TIA-1 and TIAR activate splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on their own pre-mRNAs.

3. The adeno-associated virus type 2 Rep protein regulates RNA processing via interaction with the transcription template.

Review 4. Mechanisms of alternative pre-messenger RNA splicing.

5. The RNA-binding protein TIA-1 is a novel mammalian splicing regulator acting through intron sequences adjacent to a 5' splice site.

6. Predictive identification of exonic splicing enhancers in human genes.

7. The apoptosis-promoting factor TIA-1 is a regulator of alternative pre-mRNA splicing.

8. Human GC-AG alternative intron isoforms with weak donor sites show enhanced consensus at acceptor exon positions.

9. An intronic polypyrimidine-rich element downstream of the donor site modulates cystic fibrosis transmembrane conductance regulator exon 9 alternative splicing.

10. Accumulation of GC donor splice signals in mammals.

1. TIA1 prevents skipping of a critical exon associated with spinal muscular atrophy.

Review 2. T-cell intracellular antigens in health and disease.

Review 3. The Multifunctional Faces of T-Cell Intracellular Antigen 1 in Health and Disease.

Review 4. T-Cell Intracellular Antigen 1-Like Protein in Physiology and Pathology.

5. An Alu-derived intronic splicing enhancer facilitates intronic processing and modulates aberrant splicing in ATM.